Cheap Flights from Panama City (PTYA) to Medellin (MDEA)

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Flight deals from Panama City to Medellin

Looking for a cheap last-minute deal or the best return flight from Panama City to Medellin? If you want to travel next month, return fares start from $245. Find the lowest prices on one-way and return tickets right here.

Medellin.$245 per passenger.Departing Wed, 16 Sep, returning Wed, 23 Sep.Return flight with Wingo.Outbound direct flight with Wingo departs from Balboa on Wed, 16 Sep, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Wed, 23 Sep, arriving in Balboa.Price includes taxes and charges.From $245, select.

Medellin.$245 per passenger.Departing Mon, 24 Aug, returning Fri, 28 Aug.Return flight with Wingo.Outbound direct flight with Wingo departs from Balboa on Mon, 24 Aug, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Fri, 28 Aug, arriving in Balboa.Price includes taxes and charges.From $245, select.

Medellin.$248 per passenger.Departing Fri, 18 Dec, returning Fri, 25 Dec.Return flight with Wingo.Outbound direct flight with Wingo departs from Balboa on Fri, 18 Dec, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Fri, 25 Dec, arriving in Balboa.Price includes taxes and charges.From $248, select.

Medellin.$287 per passenger.Departing Wed, 30 Sep, returning Sun, 4 Oct.Return flight with Wingo.Outbound direct flight with Wingo departs from Balboa on Wed, 30 Sep, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Sun, 4 Oct, arriving in Balboa.Price includes taxes and charges.From $287, select.

Medellin.$392 per passenger.Departing Thu, 6 May, returning Tue, 11 May.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 6 May, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Tue, 11 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Fri, 29 Jan, returning Tue, 2 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 29 Jan, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Tue, 2 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Sat, 3 Oct, returning Wed, 7 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 3 Oct, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Wed, 7 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Mon, 18 Jan, returning Mon, 25 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Mon, 18 Jan, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Mon, 25 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Thu, 22 Apr, returning Wed, 26 May.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 22 Apr, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Wed, 26 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Fri, 30 Oct, returning Sat, 7 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 30 Oct, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Sat, 7 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Mon, 9 Nov, returning Sat, 14 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Mon, 9 Nov, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Sat, 14 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Sat, 27 Feb, returning Sun, 7 Mar.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 27 Feb, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Sun, 7 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Fri, 5 Feb, returning Fri, 19 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 5 Feb, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Fri, 19 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$392 per passenger.Departing Tue, 10 Nov, returning Thu, 3 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 10 Nov, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Thu, 3 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $392, select.

Medellin.$393 per passenger.Departing Thu, 30 Jul, returning Fri, 31 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 30 Jul, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Fri, 31 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $393, select.

Medellin.$393 per passenger.Departing Tue, 25 Aug, returning Tue, 1 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 25 Aug, arriving in Medellin Jose Maria Cordova.Inbound direct flight with Copa departs from Medellin Jose Maria Cordova on Tue, 1 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $393, select.

Find the cheapest month to fly from Panama City to Medellin

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Medellin flights are currently cheapest in August.

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Direct flights from Panama City to Medellin

Alternative Panama City to Medellin routes

Looking for the cheapest, fastest or easiest route from Panama City to Medellin? You could fly into the following airports instead.

Medellin Enrique Olaya Herrera

3km from central Medellin

Closest

from $643

Search flights

Medellin Jose Maria Cordova

19km from central Medellin

Cheapest

from $245

Search flights

Panama City to Medellin: Flight information

The things to know before you go.

Cheapest flight found	$245
Cheapest month to fly	August
Average flight time	1 hr, 21 mins
Most popular airline	Copa
Average flights per week	143

Finding cheap flights from Panama City to Medellin: Frequently asked questions

How many airports are there in Medellin?

There are 2 airports in Medellin: Medellin Enrique Olaya Herrera and Medellin Jose Maria Cordova.

How much are return flights from Panama City to Medellin?

The best price we found for a return flight from Panama City to Medellin is $245. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Panama City to Medellin?

1 hour and 21 minutes is the average flight time from Panama City to Medellin.

Which airlines fly direct from Panama City to Medellin?

Copa, United and KLM fly direct from Panama City to Medellin.

How many flights are there a week from Panama City to Medellin?

As of July 2026, there are 143 flights per week flying from Panama City to Medellin.

When is the cheapest time to fly from Panama City to Medellin?

The cheapest month to fly from Panama City to Medellin is usually August.

Which is the cheapest airport to fly into in Medellin?

If you're flying from Panama City, the cheapest airport near Medellin is Medellin Jose Maria Cordova – which is 18.9 km away from the centre of Medellin. We've found flights into this airport from $245.

Which upcoming date is cheapest to fly from Panama City to Medellin on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Medellin on Monday, 24 August 2026.

Can I get a direct flight from Panama City to Medellin?

Yes – the average flight time is 1 hour and 21 minutes.

How can I get the best flight deal from Panama City to Medellin?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Medellin but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Medellin?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Medellin is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Medellin?

In July, the average temperature is usually around 18°C. May is typically the warmest month in Medellin, when it usually averages around 21°C. You can expect the least rain in January. The coldest month is November, with temperatures averaging 15°C. The rainiest month is May.

Which is the cheapest airline to fly from Panama City to Medellin with?

The cheapest airline that flies to Medellin is Wingo .

Travelling from Panama City to Medellin: what you need to know

Panama City is home to a couple of airports where you can kick off your trip. Check out your options for booking a flight from Panama City to Medellin leaving from Panama City Tocumen International Airport (PTY) or Balboa Airport (BLB).
Come in for landing at Medellin Jose Maria Cordova Airport (MDE), the major arrival point in Medellin.
Around 1 hour 20 minutes is how long you'll be in transit on a direct Panama City to Medellin flight.
Panama City and Medellin are in the UTC-5 timezone. This means you won't have to change your watch on arrival.
Panama City Tocumen International Airport (PTY) to Medellin Jose Maria Cordova Airport (MDE) is the most popular route between these two cities. There are 54 weekly flights to choose from. If you prefer a later start to the day, the last flight from Panama City to Medellin is with Copa Airlines at 21:27. Choose the first PTY to MDE departure with Copa Airlines at 06:53 to fit in more activities on your first day in Medellin.
To ensure you don't miss your Panama City to Medellin flight, allow plenty of time to check in and drop off your luggage. Arriving two hours ahead of international departures and an hour before domestic flights is the general travel rule.
During popular months such as July, it's best to get to the airport even earlier. Plan to arrive two hours before a domestic departure and four hours ahead for an international flight when you travel during a peak period in general.

How to find the cheapest flights from Panama City to Medellin

To snag cheap Panama City to Medellin flights, book your journey two months before your departure.
The best month for scoring cheap plane tickets from Panama City to Medellin is July. Use the 'Whole month' tool to compare all available prices, then choose the dates that offer the biggest savings.
Stay on top of deals for cheap flights from Panama City to Medellin by setting up a Price Alert. You'll get an email or notification through the app when a special offer becomes available.
Find a cheap Panama City to Medellin flight with the help of our filters. Select your preferred times, number of stops and airlines, then sort the results by 'Cheapest' for the best deals.

Flying from Panama City

Panama City Tocumen International Airport (PTY)

Depart from Panama City Tocumen International Airport (PTY) on a nonstop flight from Panama City to Medellin. From PTY, you can land directly at Medellin Jose Maria Cordova Airport (MDE).
Be on the lookout for promotions with Copa Airlines. This carrier offers direct Panama City to Medellin plane tickets from PTY.
Think about adding a stopover to potentially save on your Panama City to Medellin flight. Simply uncheck 'Direct flights only' when searching for departures from Panama City Tocumen International Airport. Take a break (and maybe save some cash) by stopping at one of these popular airports:
- Bogota Airport (BOG)
- Cali Airport (CLO)
- Cartagena Airport (CTG)
PTY is around 18 kilometres from central Panama City. If you're driving, ride-sharing or catching a taxi from the centre, it'll take 35 minutes or so to get there, depending on traffic conditions. If you're using public transport, expect the journey time to be around 50 minutes.
Catching an early flight from Panama City to Medellin? Avoid the stress of rushing to the airport (and sneak in some extra snooze time) by choosing one of these hotels close to Panama City Tocumen International Airport:
Panama City Tocumen International Airport earns top marks for on-time performance. 88% of flights that depart PTY reach their destination without delay.

Balboa Airport (BLB)

You can take a direct flight from Panama City to Medellin out of Balboa Airport (BLB). Start your trip at BLB and touch down at Medellin Jose Maria Cordova Airport (MDE).
You can book a direct Panama City to Medellin plane ticket with Wingo. This is one of the leading carriers operating this route out of BLB.
Get the most out of your holiday with a stopover on your Panama City to Medellin flight. Visit family or friends or cross another city off your list. Whatever your plans, here's where you can stop between Balboa Airport and Medellin:
- Bogota Airport (BOG)
- Cali Airport (CLO)
- Cartagena Airport (CTG)
You can get to BLB from the centre of Panama City in about 10 minutes by car, depending on traffic. The ride on public transport takes roughly 20 minutes to travel the 5 kilometres or so.
Want to enjoy an extra night away before boarding your flight from Panama City to Medellin? Unwind in a hotel near Balboa Airport before your holiday officially starts. Stay at one of these accommodation options:
Flights from Balboa Airport have a reputation for punctuality, with 88% of them touching down as expected.

Arriving in Medellin

Medellin Jose Maria Cordova Airport (MDE)

The distance from Medellin Jose Maria Cordova Airport (MDE) to central Medellin is approximately 18 kilometres. It'll take you about 45 minutes to reach the centre driving.
Getting there on public transport takes about 1 hour 15 minutes.
If you're arriving on a late flight from Panama City to Medellin, few things beat the convenience of staying near the terminal. Grab your luggage from the carousel and then be showered and sleeping soon after at one of these accommodation options near MDE:
Go where the road takes you with a Medellin Jose Maria Cordova Airport rental car. Pick up a set of wheels from Localiza, Green Motion or Confort Rent a Car and chase adventure across Medellin and beyond.
Reserving your ride from Medellin Jose Maria Cordova Airport around one week ahead boosts your odds of scoring a great price.

Medellin Enrique Olaya Herrera Airport (EOH)

Central Medellin is located around 3 kilometres from Medellin Enrique Olaya Herrera Airport (EOH). Once your flight from Panama City to Medellin has hit the runway and you've made your way through the terminal, expect a drive of about 15 minutes.
You can expect the trip to take roughly 25 minutes on public transport.
After your flight from Panama City to Medellin, settle in at a hotel near EOH. These are some great options that'll help you slip into relaxation mode:
Grab a Medellin Enrique Olaya Herrera Airport rental car and be your own tour guide. You can choose from leading outlets like Confort Rent a Car and Green Motion.
Call dibs on the best options. Securing your ride from EOH one week in advance often means lower prices and a greater range of vehicles.

Best time to go to Medellin

December is the most popular month for flights from Panama City to Medellin. To travel when it's less crowded, visit Medellin in March.
The warmest month in Medellin is August, with temperatures ranging between 9ºC (48ºF) and 27ºC (81ºF). Book your Panama City to Medellin ticket then if this is the type of weather you enjoy.
December sees average temperatures of between 9ºC (48ºF) and 24ºC (75ºF). Search for cheap flights from Panama City to Medellin around that time if you like travelling in cooler conditions.

More about Medellin

When it comes to searching for somewhere to rest your head, you'll find the most popular stays in Medellin right here. Explore these options as soon as you've booked your flight from Panama City to Medellin:
Palacio de Bellas Artes and Museo comuna 13 are just two of the major attractions to add to your Medellin itinerary. Continue your sightseeing adventures at Laguna de Guatape.

Explore more of Colombia

Medellin is always a good idea, but there are so many other parts of Colombia waiting to be explored. About 241 kilometres southeast of Medellin, a trip to Bogota will fill your itinerary to the brim. Start with leading sights like Teatro Colon Bogota, Gold Museum and Museum of Contemporary Art of Bogota.
Cali is another essential stop in Colombia and is around 322 kilometres south of Medellin. No trip is complete without visiting Cristo Rey, Parque Simón Bolívar and San Felipe Lodge. Birding & Wellness RN.