Cheap Flights from Denver (DEN) to Knoxville (TYS)

Compare Denver International to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

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Flight deals from Denver International to Knoxville

Looking for a cheap last-minute deal or the best return flight from Denver International to Knoxville? Find the lowest prices on one-way and return tickets right here.

Knoxville.$131 per passenger.Departing Thu, 4 Sep, returning Sun, 7 Sep.Return flight with Frontier Airlines.Outbound direct flight with Frontier Airlines departs from Denver International on Thu, 4 Sep, arriving in Knoxville.Inbound direct flight with Frontier Airlines departs from Knoxville on Sun, 7 Sep, arriving in Denver International.Price includes taxes and charges.From $131, select.

Knoxville.$148 per passenger.Departing Thu, 25 Sep, returning Thu, 9 Oct.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Denver International on Thu, 25 Sep, arriving in Knoxville.Inbound direct flight with Allegiant Air departs from Knoxville on Thu, 9 Oct, arriving in Denver International.Price includes taxes and charges.From $148, select.

Knoxville.$166 per passenger.Departing Sun, 31 Aug, returning Thu, 4 Sep.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Denver International on Sun, 31 Aug, arriving in Knoxville.Inbound direct flight with Allegiant Air departs from Knoxville on Thu, 4 Sep, arriving in Denver International.Price includes taxes and charges.From $166, select.

Knoxville.$188 per passenger.Departing Thu, 2 Oct, returning Thu, 9 Oct.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Denver International on Thu, 2 Oct, arriving in Knoxville.Inbound direct flight with Allegiant Air departs from Knoxville on Thu, 9 Oct, arriving in Denver International.Price includes taxes and charges.From $188, select.

Knoxville.$200 per passenger.Departing Thu, 28 Aug, returning Sun, 31 Aug.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Denver International on Thu, 28 Aug, arriving in Knoxville.Inbound direct flight with Allegiant Air departs from Knoxville on Sun, 31 Aug, arriving in Denver International.Price includes taxes and charges.From $200, select.

Knoxville.$211 per passenger.Departing Sun, 26 Oct, returning Sun, 2 Nov.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Denver International on Sun, 26 Oct, arriving in Knoxville.Inbound direct flight with Allegiant Air departs from Knoxville on Sun, 2 Nov, arriving in Denver International.Price includes taxes and charges.From $211, select.

Knoxville.$412 per passenger.Departing Fri, 14 Nov, returning Mon, 17 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Denver International on Fri, 14 Nov, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Mon, 17 Nov, arriving in Denver International.Price includes taxes and charges.From $412, select.

Knoxville.$515 per passenger.Departing Fri, 12 Dec, returning Thu, 18 Dec.Return flight with United.Outbound indirect flight with United, departs from Denver International on Fri, 12 Dec, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Thu, 18 Dec, arriving in Denver International.Price includes taxes and charges.From $515, select.

Find the cheapest month to fly from Denver International to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Denver International to Knoxville flights are currently cheapest in September.

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Direct flights from Denver International to Knoxville

Denver International to Knoxville: Alternative routes

Compare routes from Denver International to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Denver to Knoxville: Flight information

The things to know before you go.

Cheapest flight found	$131
Cheapest month to fly	September
Average flight time	2 hrs, 50 mins
Most popular airline	United
Average flights per week	19

Finding cheap flights from Denver International to Knoxville: Frequently asked questions

How much are return flights from Denver International to Knoxville?

The best price we found for a return flight from Denver International to Knoxville is $131. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Denver International to Knoxville?

2 hours and 50 minutes is the average flight time from Denver International to Knoxville.

Which airlines fly direct from Denver International to Knoxville?

United, SkyWest Airlines and Allegiant Air fly direct from Denver International to Knoxville.

How many flights are there a week from Denver International to Knoxville?

As of August 2025, there are 19 flights per week flying from Denver International to Knoxville.

When is the cheapest time to fly from Denver International to Knoxville?

The cheapest month to fly from Denver International to Knoxville is usually September.

Which upcoming date is cheapest to fly from Denver International Airport to Knoxville Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Denver International Airport to Knoxville Airport on Thursday, 4 September 2025.

Can I get a direct flight from Denver International Airport to Knoxville Airport?

Yes – the average flight time is 2 hours and 50 minutes.

How can I find the best flight deal to Knoxville?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Knoxville?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Denver International Airport to Knoxville with?

Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Flying from Denver International Airport (DEN) to McGhee Tyson Airport (TYS): what you need to know

Hop on a direct flight from Denver International Airport to McGhee Tyson Airport and you'll be in the air for an average of 2 hours 50 minutes.
Flights from DEN to TYS start at 07:46 — the first with Allegiant Air. The latest departure is at 17:59 with Allegiant Air. In total, you can choose from 25 weekly Denver International Airport to McGhee Tyson Airport flights.
Arriving two hours before an international flight and one hour ahead of a domestic departure are golden rules for hassle-free flying. Be at the airport on time to board your DEN to TYS flight.
You can expect longer lines during popular months such as July. Arriving up to four hours in advance for an international flight and two hours for domestic departures is a good idea.
You can travel nonstop to Knoxville, United States. Take off with one of these carriers that operate direct flights from Denver International Airport to McGhee Tyson Airport:
The airline that tops the list for bookings on this route is Frontier Airlines.
With a reliable 83.33% of services arriving on schedule, United Airlines has the best on-time record for DEN to TYS flights.
If you want to split up your journey, simply deselect 'Direct flights only' when searching for your ticket from Denver International Airport to McGhee Tyson Airport. These are the top stopovers between DEN and TYS:
- Hartsfield-Jackson Atlanta International Airport
- Chicago Midway International Airport
- Austin-Bergstrom International Airport

How to find the cheapest flights from Denver International Airport (DEN) to McGhee Tyson Airport (TYS)

$68 is the best price for a one-way Denver International Airport to McGhee Tyson Airport flight. Return flights start at $131. These prices may change based on demand.
To get cheap tickets from DEN to TYS, book your journey eight months ahead of your departure.
Plan your trip for July. That's the cheapest month for flights from Denver International Airport to McGhee Tyson Airport. If you're flexible with your travel dates, try out the 'Whole month' tool to find the cheapest price across each month.
There's no need to check back in every day to see if fares have dropped when you create a Price Alert. We'll let you know as soon as there's a change in price on cheap flights from DEN to TYS.
Tailor your flights using filters. Select your preferred departure and arrival times, airlines and total journey duration. You can also sort the results by 'Best,' 'Fastest' or 'Cheapest' flights from Denver International Airport to McGhee Tyson Airport.

Handy information about Denver International Airport (DEN)

The address for DEN is 8500 Pena Boulevard.
80.23% of flights departing from Denver International Airport arrive at their destination as planned. Given its impressive on-time stats, you're unlikely to be delayed when jetting out of DEN.
To reach Denver International Airport from central Denver, it'll take around 35 minutes if you're travelling by car. This depends on traffic though. It's approximately 40 kilometres from the airport to the city centre.
You can expect a journey time of around 1 hour 30 minutes when using public transport.
Booking a night at a hotel can take the hassle out of reaching the airport on time. If you want somewhere to stay before your flight from Denver International Airport to McGhee Tyson Airport, take a look at Baymont by Wyndham Denver International Airport. It's a short drive from DEN.

Arriving at McGhee Tyson Airport (TYS)

Consider staying in a hotel close to TYS if you have a late Denver International Airport to McGhee Tyson Airport flight. Settle into one of these accommodation options and make your arrival easier:
Begin your adventure by picking up a McGhee Tyson Airport rental car. Grab your wheels from Budget, Alamo or Avis and explore beyond Knoxville's usual tourist stops.
To lock in the lowest price, book your vehicle from McGhee Tyson Airport around three weeks in advance.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

You'll find TYS at 2055 Alcoa Highway.
McGhee Tyson Airport is approximately 23 kilometres from the centre of Knoxville. The drive time takes around 20 minutes.

When to fly to McGhee Tyson Airport (TYS)

July is the busiest month for flights from Denver International Airport to McGhee Tyson Airport. For smaller crowds, visit Knoxville in February.
Book your flight from Denver International Airport to McGhee Tyson Airport for July if you want to explore Knoxville during its warmest month. You can expect temperatures of between 17ºC (63ºF) and 32ºC (90ºF).
Search for cheap tickets from DEN to TYS in January if you like cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC (21ºF) and 11ºC (52ºF) on average.

Explore more of United States

Columbus is just one of the many places in United States waiting to be discovered once you've seen the sights of Knoxville. Around 451 kilometres away to the north, its best attractions include Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.
Indianapolis is another sought-after destination in United States and is around 467 kilometres north-west of Knoxville. No trip is complete without a visit to The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.