Santo Domingo to Panama Flights

Looking for a cheap flight ticket from Santo Domingo to Panama? Whether you're looking for a direct flight, return flight or one way ticket we've got you.

Panama City.$493 per passenger.Departing Fri, 30 May, returning Mon, 2 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 30 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 2 Jun, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $493, select.

David.$801 per passenger.Departing Fri, 6 Jun, returning Wed, 25 Jun.Return flight with Copa.Outbound indirect flight with Copa, departs from Santo Domingo Las Americas on Fri, 6 Jun, arriving in David.Inbound indirect flight with Copa, departs from David on Wed, 25 Jun, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $801, select.

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Flights from Santo Domingo to Panama FAQs

What is the cheapest flight to Panama from Santo Domingo?

The cheapest flight from Santo Domingo to Panama costs $493.

Explore the different prices of flights from Santo Domingo to Panama and find the best option for you.

When is it the cheapest time to fly from Santo Domingo to Panama?

The cheapest month to fly from Santo Domingo to Panama is May. See if any of these flights in May suit you.

What is the cheapest Santo Domingo to Panama flight route?

We've taken a look at the year ahead using our flights calendar. The cheapest flight route from Santo Domingo to Panama is Santo Domingo to Panama City Tocumen International. You can buy a ticket to fly this route from $493.

Take a look at Santo Domingo to Panama City Tocumen International flights.

How long is the flight from Santo Domingo to Panama?

The average flight time from Santo Domingo to Panama is 2 hours and 36 minutes.

What is the cheapest airline that flies to Panama from Santo Domingo?

Looking at the year ahead, the cheapest airline flying to Panama from Santo Domingo is Avianca.

Explore Avianca flight ticket options today.

If this airline doesn't suit you, the second cheapest airline is Copa.

Cheapest flights to Panama from Santo Domingo

Santo Domingo to Panama City from $493
Price found 20 May 2025, 16:10
Santo Domingo to David from $801
Price found 17 May 2025, 13:23

How to find cheap flights from Santo Domingo to Panama

Looking for flight tickets from Santo Domingo to Panama? Return tickets start from $493 and one-way flights from Santo Domingo to Panama start from $215

Here are some tips on how to secure the best flight price and make your journey as smooth as possible.

Simply hit 'search'. From British Airways to international carriers like Emirates, we've compared flights from all major airlines and online travel agents to find the cheapest Santo Domingo to Panama flights. And with us there are no hidden fees - what you see is what you pay.
Compare cheap Santo Domingo to Panama flight deals from over 1,000 providers. Then choose the cheapest or fastest plane tickets. Flight tickets to Panama start from $215 one-way.
Flex your dates to secure the best fares for your Santo Domingo to Panama ticket. If your travel dates are flexible, use Skyscanner's 'Whole month' tool to find the cheapest month, and even day to fly from Santo Domingo to Panama.
Set up a Price Alert. We price check with over 1,000 travel companies so you don't have to. You can easily track the price of your airline tickets from Santo Domingo to Panama by creating an alert. Whenever prices go down or up, you'll get an email or push notification to help make sure you get the best possible flight deal.
Look for direct flights. Only interested in direct flights from Santo Domingo to Panama? Make sure to tick 'Direct flights only' when performing a search. If there are direct Santo Domingo to Panama flights available, these will appear in the results.
Find the cheapest Business Class flights from Santo Domingo to Panama. Check the difference in price of your plane ticket to Panama from Santo Domingo when travelling in Economy, Premium Economy, Business or First Class. Note that not all cabin classes are available for every destination or airline.
Include nearby airports in your search. Widen your search for Santo Domingo to Panama flight deals by selecting the "add nearby airports" option. This will allow you to see flight prices for all the nearest airports at your departure and destination point and could help you save money.
Search for flights on the go. To get the best flight booking experience on the go, download our app and search for cheap flight tickets from Santo Domingo to Panama when out and about.

Combine your flight from Santo Domingo to Panama with hotels and car hire

Once you've secured your plane ticket we will also help you discover the best prices and exclusive rates for hotels in Panama or close by. Lastly, compare hundreds of car hire companies in one go so that you get the best car hire deals for your trip.

Compare Santo Domingo to Panama flight tickets with other routes using the everywhere search

Not entirely set on flying to Panama from Santo Domingo yet? You can easily browse other destinations by searching flights to 'Everywhere' - this will allow you to find the cheapest place to travel to.

Panama hotels and car hire

Did you know we can help you plan the rest of your trip from Santo Domingo to Panama? Get exclusive deals and great rates for hotels and car hire in Panama.