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Cheap Flights from Panama City (PTYA) to Santo Domingo (SDQ)

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      Travellers and cabin class, 1 Adult, Economy
      Copa
      KLM
      Air France
      Turkish Airlines

      Compare Panama City to Santo Domingo Las Americas flight deals

      Find the cheapest month or even day of the year to fly to Santo Domingo Las Americas

      Book the best Santo Domingo Las Americas fare with no extra fees

      Flight deals from Panama City to Santo Domingo Las Americas

      Looking for a cheap last-minute deal or the best return flight from Panama City to Santo Domingo Las Americas Airport? If you want to travel next month, return fares start from $680. Find the lowest prices on one-way and return tickets right here.
      Santo Domingo.$680 per passenger.Departing Fri, 4 Dec, returning Tue, 8 Dec.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 4 Dec, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 8 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $680, select.
      Santo Domingo.$680 per passenger.Departing Sat, 19 Sep, returning Sat, 26 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 19 Sep, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 26 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $680, select.
      Santo Domingo.$680 per passenger.Departing Mon, 12 Oct, returning Mon, 19 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 12 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 19 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $680, select.
      Santo Domingo.$681 per passenger.Departing Wed, 25 Nov, returning Sat, 28 Nov.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 25 Nov, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 28 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $681, select.
      Santo Domingo.$683 per passenger.Departing Tue, 3 Nov, returning Thu, 5 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 3 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 5 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$683 per passenger.Departing Thu, 1 Oct, returning Fri, 9 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 1 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Fri, 9 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$684 per passenger.Departing Wed, 30 Sep, returning Mon, 5 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 30 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Mon, 5 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$684 per passenger.Departing Wed, 9 Dec, returning Sat, 12 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 9 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 12 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$684 per passenger.Departing Fri, 30 Oct, returning Tue, 3 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 30 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 3 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$684 per passenger.Departing Sat, 26 Sep, returning Wed, 30 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 26 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 30 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$734 per passenger.Departing Tue, 8 Dec, returning Thu, 14 Jan.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 8 Dec, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 14 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $734, select.
      Santo Domingo.$739 per passenger.Departing Sat, 12 Dec, returning Sun, 10 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 12 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 10 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $739, select.
      Santo Domingo.$739 per passenger.Departing Sun, 22 Nov, returning Sun, 21 Feb.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 22 Nov, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sun, 21 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $739, select.
      Santo Domingo.$740 per passenger.Departing Fri, 20 Nov, returning Sat, 9 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 20 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 9 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $740, select.
      Santo Domingo.$745 per passenger.Departing Sun, 22 Nov, returning Sun, 21 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 22 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 21 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $745, select.
      Santo Domingo.$745 per passenger.Departing Sun, 29 Nov, returning Sat, 19 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 29 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 19 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $745, select.
      How did we find these deals? The deals you see here are the lowest prices for flight tickets from Panama City to Santo Domingo Las Americas found in the last 4 days, and are subject to change and availability.

      Find the cheapest month to fly from Panama City to Santo Domingo Las Americas

      We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Santo Domingo Las Americas flights are currently cheapest in September.
      Sep
      from $680
      Oct
      from $680
      Nov
      from $681
      Dec
      from $680
      Jan
      from $793
      Feb
      from $789
      Mar
      from $796
      Apr
      Find prices
      May
      from $793
      Jun
      Find prices
      Jul
      from $794
      Aug
      from $796

      Direct flights from Panama City to Santo Domingo Las Americas

      Air France
      Copa
      KLM
      Turkish Airlines

      Panama City to Santo Domingo Las Americas: Alternative routes

      Compare routes from Panama City to Santo Domingo below. You may find an airport to fly into that's cheaper, faster, or easier than Santo Domingo Las Americas.

      La Isabela International

      15km from central Santo Domingo
      Closest
      Search flights

      Santo Domingo Las Americas

      23km from central Santo Domingo
      Cheapest
      from $680
      Search flights

      Samana

      89km from central Santo Domingo
      Search flights

      Panama City to Santo Domingo: Flight information

      The things to know before you go.
      Cheapest flight found$680
      Cheapest month to flySeptember
      Average flight time2 hrs, 27 mins
      Most popular airlineCopa
      Average flights per week68

      Finding cheap flights from Panama City to Santo Domingo Las Americas: Frequently asked questions

      The best price we found for a return flight from Panama City to Santo Domingo Las Americas is $680. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      2 hours and 27 minutes is the average flight time from Panama City to Santo Domingo Las Americas.
      Copa, KLM and Air France fly direct from Panama City to Santo Domingo Las Americas.
      As of September 2026, there are 68 flights per week flying from Panama City to Santo Domingo Las Americas.
      The cheapest month to fly from Panama City to Santo Domingo Las Americas is usually September.
      After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Santo Domingo Las Americas Airport on Saturday, 19 September 2026.
      Yes – the average flight time is 2 hours and 27 minutes.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo Las Americas but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

      How to find cheap flights to Santo Domingo (SDQ) from Panama City (PTYA) in 2024

      Looking for cheap tickets from Panama City to Santo Domingo Las Americas? Return tickets start from $680 and one-way flights to Santo Domingo Las Americas from Panama City start from $390


      Here are a few tips on how to secure the best flight price and make your journey as smooth as possible.

      • Simply hit 'search'. From British Airways to international carriers like Emirates, we compare all major airlines along with the most popular online travel agents to find the cheapest plane tickets.
      • Compare flight deals to Santo Domingo from Panama City from over 1,000 providers. Then choose the cheapest or fastest plane tickets. Flight tickets to Santo Domingo start from $390 one-way.
      • Flex your dates to find the best PTYA-SDQ ticket prices. If you are flexible when it comes to your travel dates, use Skyscanner's 'Whole month' tool to find the cheapest month, and even day to fly to Santo Domingo Las Americas from Panama City.
      • Set up a Price Alert. You can easily track the fare of your cheap flights by creating an alert. Whenever prices go down or up, you'll get an email or push notification to help make sure you get the best possible flight deal.
      • Fly without stops. Only interested in direct flights between Panama City and Santo Domingo Las Americas? Make sure to tick 'Direct flights only' when performing a search. If there are direct flights available on the route, these will appear in the results. Airlines that fly direct include: Copa
        KLM
        Air France
        Turkish Airlines
      • Find the cheapest Business class flights from Panama City and Santo Domingo Las Americas. We scour the internet for the best Business, Premium Economy and First Class flight fares to Santo Domingo, too. Check the difference in price as you search – you might just chance upon a last-minute low fare. Note that not all cabin classes are available for every destination or airline.
      • Include nearby airports in your search. Widen your search for Panama City to Santo Domingo Las Americas flight deals by selecting the "add nearby airports" option. This will allow you to see flight prices for all the nearest airports at your departure point and your destination and could help you save next time you travel.
      • Search for cheap flights regardless of where you are. To get the best flight booking experience when out and about, download the app and search for plane tickets between Panama City and Santo Domingo Las Americas whenever you want.

      Combine your flight to Santo Domingo Las Americas from Panama City with hotels and car hire

      Once you've secured your cheap flight ticket from Panama City to Santo Domingo Las Americas, discover the best prices and exclusive rates for hotels in Santo Domingo or nearby. You can also compare hundreds of car hire companies in one go so that you get the best car hire price for your trip.


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      Plan the rest of your trip from Panama City to Santo Domingo

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.