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Cheap Flights from Panama City (PTY) to Santo Domingo (SDQA)

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      Travellers and cabin class, 1 Adult, Economy
      Copa
      KLM
      Air France
      Turkish Airlines

      Compare Panama City Tocumen International to Santo Domingo flight deals

      Find the cheapest month or even day of the year to fly to Santo Domingo

      Book the best Santo Domingo fare with no extra fees

      Flight deals from Panama City Tocumen International to Santo Domingo

      Looking for a cheap last-minute deal or the best return flight from Panama City Tocumen International Airport to Santo Domingo? If you want to travel next month, return fares start from $681. Find the lowest prices on one-way and return tickets right here.
      Santo Domingo.$681 per passenger.Departing Wed, 25 Nov, returning Sat, 28 Nov.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 25 Nov, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 28 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $681, select.
      Santo Domingo.$681 per passenger.Departing Thu, 1 Oct, returning Fri, 9 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 1 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 9 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $681, select.
      Santo Domingo.$683 per passenger.Departing Tue, 3 Nov, returning Thu, 5 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 3 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 5 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$683 per passenger.Departing Thu, 1 Oct, returning Fri, 9 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 1 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Fri, 9 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$683 per passenger.Departing Tue, 13 Oct, returning Sat, 7 Nov.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 13 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 7 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$683 per passenger.Departing Thu, 24 Sep, returning Sun, 27 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 24 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 27 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $683, select.
      Santo Domingo.$684 per passenger.Departing Wed, 9 Dec, returning Sat, 12 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 9 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 12 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$684 per passenger.Departing Fri, 30 Oct, returning Tue, 3 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 30 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 3 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$684 per passenger.Departing Tue, 29 Sep, returning Sun, 4 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 29 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 4 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $684, select.
      Santo Domingo.$739 per passenger.Departing Sat, 12 Dec, returning Sun, 10 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 12 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 10 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $739, select.
      Santo Domingo.$740 per passenger.Departing Sun, 22 Nov, returning Sun, 21 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 22 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 21 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $740, select.
      Santo Domingo.$740 per passenger.Departing Fri, 20 Nov, returning Sat, 9 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 20 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 9 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $740, select.
      Santo Domingo.$792 per passenger.Departing Sun, 28 Feb, returning Sun, 14 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 28 Feb, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sun, 14 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $792, select.
      Santo Domingo.$792 per passenger.Departing Fri, 2 Apr, returning Mon, 5 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 2 Apr, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 5 Apr, arriving in Panama City Tocumen International.Price includes taxes and charges.From $792, select.
      Santo Domingo.$792 per passenger.Departing Tue, 16 Mar, returning Tue, 23 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 16 Mar, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 23 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $792, select.
      Santo Domingo.$792 per passenger.Departing Wed, 17 Feb, returning Mon, 22 Feb.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 17 Feb, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 22 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $792, select.
      How did we find these deals? The deals you see here are the lowest prices for flight tickets from Panama City Tocumen International to Santo Domingo found in the last 4 days, and are subject to change and availability.

      Find the cheapest month to fly from Panama City Tocumen International to Santo Domingo

      We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City Tocumen International to Santo Domingo flights are currently cheapest in October.
      Sep
      from $683
      Oct
      from $681
      Nov
      from $681
      Dec
      from $684
      Jan
      from $793
      Feb
      from $792
      Mar
      from $792
      Apr
      from $792
      May
      from $793
      Jun
      Find prices
      Jul
      from $793
      Aug
      Find prices

      Direct flights from Panama City Tocumen International to Santo Domingo

      Air France
      Copa
      KLM
      Turkish Airlines

      Alternative Panama City Tocumen International to Santo Domingo routes

      Looking for the cheapest, fastest or easiest route from Panama City Tocumen International to Santo Domingo? You could fly into the following airports instead.

      La Isabela International

      15km from central Santo Domingo
      Closest
      Search flights

      Santo Domingo Las Americas

      23km from central Santo Domingo
      Cheapest
      from $681
      Search flights

      Samana

      89km from central Santo Domingo
      Search flights

      Panama City to Santo Domingo: Flight information

      The things to know before you go.
      Cheapest flight found$681
      Cheapest month to flyOctober
      Average flight time2 hrs, 27 mins
      Most popular airlineCopa
      Average flights per week68

      Finding cheap flights from Panama City Tocumen International to Santo Domingo: Frequently asked questions

      There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.
      The best price we found for a return flight from Panama City Tocumen International to Santo Domingo is $681. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      2 hours and 27 minutes is the average flight time from Panama City Tocumen International to Santo Domingo.
      Copa, KLM and Air France fly direct from Panama City Tocumen International to Santo Domingo.
      As of September 2026, there are 136 flights per week flying from Panama City Tocumen International to Santo Domingo.
      The cheapest month to fly from Panama City Tocumen International to Santo Domingo is usually October.
      If you're flying from Panama City Tocumen International Airport, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from $681.
      After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Panama City Tocumen International Airport to Santo Domingo on Thursday, 1 October 2026.
      Yes – the average flight time is 2 hours and 27 minutes.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

      In September, the average temperature is usually around 28°C. August is typically the warmest month in Santo Domingo, when it usually averages around 32°C. You can expect the least rain in January. The coldest month is January, with temperatures averaging 20°C. The rainiest month is August.
      Currently, Avianca and Copa offer the cheapest flight tickets to Santo Domingo.

      Flying from Panama City Tocumen International Airport (PTY) to Santo Domingo: what you need to know

      • Take a direct flight from Panama City Tocumen International Airport to Santo Domingo and you'll be in the air for an average of 2 hours 35 minutes.

      • Santo Domingo is one hour ahead of Panama City, where Panama City Tocumen International Airport is located. Santo Domingo follows the UTC-4 timezone.

      • The most popular route is from Panama City Tocumen International Airport (PTY) to Santo Domingo Las Americas International Airport (SDQ). There are 33 weekly services between these two airports. If you want to get going as soon as possible, the earliest flight from PTY to SDQ is the 07:18 Copa Airlines option. If you prefer to travel later, the last departure is at 23:13 with Copa Airlines.

      • For a stress-free journey, arrive at the airport two hours ahead of international flights and an hour before domestic departures. This ensures you have enough time to board your PTY to Santo Domingo flight.

      • You can expect longer queues in popular months like January. Arriving up to four hours ahead of international flights and two hours for a domestic departure is a good idea.

      • Begin your trip at PTY and fly nonstop to Santo Domingo Las Americas International Airport (SDQ). That's where you can expect to touch down when searching for Panama City Tocumen International Airport to Santo Domingo tickets.

      • Copa Airlines is a well-known airline that operates direct flights from Panama City Tocumen International Airport to Santo Domingo.

      • We make it simple to book plane tickets from PTY to Santo Domingo with a stopover. To see all your options, uncheck 'Direct flights only.' Next, pick a flight offering a stop long enough to explore the city of your choice. Some popular stopovers include:

        • Miami International Airport (MIA)

        • Luis Munoz Marin International Airport (SJU)

        • Queen Beatrix International Airport (AUA)

      • The journey from central Panama City to PTY takes about 50 minutes on public transport. If you drive, ride-share or grab a taxi, you'll cover the 18 kilometres in 35 minutes or so, depending on traffic conditions.

      • Want a hassle-free start to your travels? Stay near PTY. Whether you're boarding an early flight from Panama City Tocumen International Airport to Santo Domingo or want to avoid feeling rushed, these hotels are just the thing:

      • 88% of flights leaving Panama City Tocumen International Airport arrive at their destination on time. With its dependable on-time performance, you're unlikely to be delayed when jetting out of PTY.

      How to find the cheapest flights from Panama City Tocumen International Airport (PTY) to Santo Domingo

      • $392 is currently the best price for a one-way Panama City Tocumen International Airport to Santo Domingo flight. A return plane ticket starts from $681. These prices may change depending on availability and demand.

      • Score cheap flights from PTY to Santo Domingo by booking 11 months ahead. Based on our research, that's the sweet spot for picking up a bargain.

      • Organise your trip for April. That's the best month for scoring a bargain on Panama City Tocumen International Airport to Santo Domingo tickets. If you have flexibility with your dates, use the 'Whole month' tool to access the cheapest price across every month.

      • You don't need to check back constantly to find out if fares have dropped when you create a Price Alert. We'll notify you the moment there's an updated deal for cheap flights from PTY to Santo Domingo.

      • Tailor your trip with filters. Choose your ideal arrival and departure times, airlines and total journey duration. You can also sort the results by 'Best,' 'Fastest' or 'Cheapest' flights from Panama City Tocumen International Airport to Santo Domingo.

      Airports in Santo Domingo

      Santo Domingo Las Americas International Airport (SDQ)

      • The distance from Santo Domingo Las Americas International Airport (SDQ) to central Santo Domingo is roughly 29 kilometres. It'll take you about 35 minutes to reach the centre driving.

      • When travelling by public transport, expect a journey time of around 1 hour 15 minutes.

      • Think about booking a hotel near SDQ if you have a late flight from Panama City Tocumen International Airport to Santo Domingo. Check in to one of these accommodation options and make your arrival easier:

      • Booking your ride from Santo Domingo Las Americas International Airport about one week before your flight from PTY to Santo Domingo can help you lock in the lowest rate.

      La Isabela Dr Joaquin Balaguer Intl Airport (JBQ)

      • The centre of Santo Domingo is located around 23 kilometres from La Isabela Dr Joaquin Balaguer Intl Airport (JBQ). After your flight from Panama City Tocumen International Airport to Santo Domingo has touched down and you've made your way through the terminal, expect a drive of around 30 minutes.

      • You can expect the trip to take roughly 50 minutes on public transport.

      • Hang the 'Do not disturb' sign on your door and relax at a hotel close to JBQ. Here are a few options where you can tuck yourself in after your PTY to Santo Domingo flight:

      • Typically, the earlier you book, the more you save and the better your options. Secure your ride from JBQ once your travel dates are set.

      Best time to go to Santo Domingo

      • It's time to plan your dates for your flight from Panama City Tocumen International Airport to Santo Domingo. August is the most popular month to travel to Santo Domingo. If you like a quieter vibe, go in December.

      • The warmest month in Santo Domingo is September, with temperatures ranging between 23ºC (73ºF) and 33ºC (91ºF). Book your Panama City Tocumen International Airport to Santo Domingo plane ticket then if that's the weather you find most pleasant.

      • February sees average temperatures of between 19ºC (66ºF) and 29ºC (84ºF). Search for a cheap ticket from PTY to Santo Domingo around that time if you like cooler conditions.

      More about Santo Domingo

      • When it comes to searching for somewhere to lay your head, you'll find the top stays in Santo Domingo right here. Explore these hotels as soon as you've locked in your flight from Panama City Tocumen International Airport to Santo Domingo:

      • Every great holiday has to include a little sightseeing. Alcazar de Colon, Catedral Primada de las Americas and The Cathedral of the Americas are attractions you won't want to skip in Santo Domingo.

      Explore more of the Dominican Republic

      • Santo Domingo is always a good idea, but there are so many other parts of the Dominican Republic you'll want to see. Around 105 kilometres east of Santo Domingo, a visit to La Romana will fill your itinerary to the brim. Don't miss top attractions like Altos de Chavon, Minitas Beach and Dye Fore Golf Course of Casa de Campo.

      • Around 161 kilometres northwest of Santo Domingo, Puerto Plata is another favourite stop in the Dominican Republic. Get a taste of what this destination has to offer at Long Beach, Golden Beach (Playa Dorada) and Puerto Plata Cable Car.

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      Plan the rest of your trip from Panama City to Santo Domingo

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.