Cheap Flights from Medellin (MDEA) to Santo Domingo (SDQA)

Compare Medellin to Santo Domingo flight deals

Find the cheapest month or even day of the year to fly to Santo Domingo

Book the best Santo Domingo fare with no extra fees

Flight deals from Medellin to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Medellin to Santo Domingo? If you want to travel next month, return fares start from $412. Find the lowest prices on one-way and return tickets right here.

Santo Domingo.$411 per passenger.Departing Wed, 23 Sep, returning Wed, 30 Sep.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Wed, 23 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Wed, 30 Sep, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $411, select.

Santo Domingo.$412 per passenger.Departing Tue, 17 Nov, returning Sat, 21 Nov.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Tue, 17 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sat, 21 Nov, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $412, select.

Santo Domingo.$412 per passenger.Departing Tue, 14 Jul, returning Thu, 16 Jul.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Tue, 14 Jul, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Thu, 16 Jul, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $412, select.

Santo Domingo.$412 per passenger.Departing Fri, 7 Aug, returning Tue, 11 Aug.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Fri, 7 Aug, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 11 Aug, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $412, select.

Santo Domingo.$423 per passenger.Departing Wed, 30 Sep, returning Sun, 4 Oct.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Wed, 30 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sun, 4 Oct, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $423, select.

Santo Domingo.$423 per passenger.Departing Sat, 10 Oct, returning Sat, 17 Oct.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Sat, 10 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sat, 17 Oct, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $423, select.

Santo Domingo.$429 per passenger.Departing Thu, 30 Jul, returning Mon, 3 Aug.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Thu, 30 Jul, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Mon, 3 Aug, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $429, select.

Santo Domingo.$429 per passenger.Departing Tue, 1 Dec, returning Tue, 8 Dec.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Tue, 1 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 8 Dec, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $429, select.

Santo Domingo.$434 per passenger.Departing Mon, 31 Aug, returning Sun, 13 Sep.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Mon, 31 Aug, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sun, 13 Sep, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $434, select.

Santo Domingo.$435 per passenger.Departing Fri, 30 Oct, returning Wed, 4 Nov.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Fri, 30 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Wed, 4 Nov, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $435, select.

Santo Domingo.$441 per passenger.Departing Fri, 27 Nov, returning Tue, 1 Dec.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Fri, 27 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 1 Dec, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $441, select.

Santo Domingo.$446 per passenger.Departing Mon, 11 Jan, returning Sun, 17 Jan.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Mon, 11 Jan, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sun, 17 Jan, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $446, select.

Santo Domingo.$446 per passenger.Departing Fri, 12 Feb, returning Sun, 14 Feb.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Fri, 12 Feb, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sun, 14 Feb, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $446, select.

Santo Domingo.$469 per passenger.Departing Sat, 19 Dec, returning Tue, 12 Jan.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Sat, 19 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 12 Jan, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $469, select.

Santo Domingo.$470 per passenger.Departing Sat, 20 Mar, returning Sun, 28 Mar.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Sat, 20 Mar, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sun, 28 Mar, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $470, select.

Santo Domingo.$476 per passenger.Departing Fri, 19 Feb, returning Fri, 19 Mar.Return flight with Arajet.Outbound indirect flight with Arajet, departs from Medellin Jose Maria Cordova on Fri, 19 Feb, arriving in Santo Domingo Las Americas.Inbound indirect flight with Arajet, departs from Santo Domingo Las Americas on Fri, 19 Mar, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From $476, select.

Find the cheapest month to fly from Medellin to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Medellin to Santo Domingo flights are currently cheapest in September.

Jul

Aug

Sep

Oct

Nov

Dec

Jan

Feb

Mar

Apr

May

Jun

Direct flights from Medellin to Santo Domingo

Alternative Medellin to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Medellin to Santo Domingo? You could fly into the following airports instead.

Medellin to Santo Domingo: Flight information

The things to know before you go.

Cheapest flight found	$411
Cheapest month to fly	September
Average flight time	2 hrs, 32 mins
Most popular airline	Arajet
Average flights per week	30

Finding cheap flights from Medellin to Santo Domingo: Frequently asked questions

How many airports are there in Santo Domingo?

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.

How much are return flights from Medellin to Santo Domingo?

The best price we found for a return flight from Medellin to Santo Domingo is $411. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Medellin to Santo Domingo?

2 hours and 32 minutes is the average flight time from Medellin to Santo Domingo.

Which airlines fly direct from Medellin to Santo Domingo?

Arajet, World Ticket Ltd and Copa Airlines Colombia fly direct from Medellin to Santo Domingo.

How many flights are there a week from Medellin to Santo Domingo?

As of July 2026, there are 30 flights per week flying from Medellin to Santo Domingo.

When is the cheapest time to fly from Medellin to Santo Domingo?

The cheapest month to fly from Medellin to Santo Domingo is usually September.

Which is the cheapest airport to fly into in Santo Domingo?

If you're flying from Medellin, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from $411.

Which upcoming date is cheapest to fly from Medellin to Santo Domingo on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Medellin to Santo Domingo on Wednesday, 23 September 2026.

Can I get a direct flight from Medellin to Santo Domingo?

Yes – the average flight time is 2 hours and 32 minutes.

How can I get the best flight deal from Medellin to Santo Domingo?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Santo Domingo?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Santo Domingo?

In July, the average temperature is usually around 28°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.

Which is the cheapest airline to fly from Medellin to Santo Domingo with?

The cheapest airline that flies to Santo Domingo is Arajet .

Travelling from Medellin to Santo Domingo: what you need to know

Medellin's main base, Medellin Jose Maria Cordova Airport (MDE), is where many unforgettable trips begin. Explore your departure options from here for your flight from Medellin to Santo Domingo.
Hop off your plane in Santo Domingo at Santo Domingo Las Americas Airport (SDQ) or La Isabela International Airport (JBQ).
Around 2 hours 30 minutes is how long you can expect to be travelling on a direct Medellin to Santo Domingo flight.
Santo Domingo's timezone is UTC-4, making Santo Domingo one hour ahead of Medellin.
With 11 flights a week between the two airports, Medellin Jose Maria Cordova Airport (MDE) to Santo Domingo Las Americas Airport (SDQ) is the busiest route. Board the first flight from Medellin to Santo Domingo with Wingo at 05:47. If you'd like to make the most of your day before jetting off, the latest departure from MDE to SDQ is with Arajet at 21:27.
To ensure you catch your Medellin to Santo Domingo flight, allow plenty of time to check in and drop off your luggage. Turning up two hours before international departures and one hour before domestic flights is the general rule.
During popular months like December, it's best to get to the airport earlier than normal. Plan to arrive two hours before domestic departures and four hours ahead of an international flight when you travel during high season in general.

How to find the cheapest flights from Medellin to Santo Domingo

$258 is currently the best price for a one-way ticket from Medellin to Santo Domingo. Return flights start at $411. These fares may change depending on demand.
Score cheap Medellin to Santo Domingo flights by booking four months ahead. Based on our research, that's the sweet spot for bagging a bargain.
Schedule your trip for September. That's the best month for scoring an incredible deal on plane tickets from Medellin to Santo Domingo. If you have flexibility with your dates, use the 'Whole month' tool to see the cheapest price across each month.
Finding a cheap flight from Medellin to Santo Domingo couldn't be easier with Price Alerts. Simply create one of these automatic alerts and we'll let you know as soon as there's a better deal.
Choose your preferred departure and arrival times, airlines and number of stops by using the filters. Or sort your Medellin to Santo Domingo flight results by 'Fastest,' 'Cheapest' or 'Best.'

Flying from Medellin

Medellin Jose Maria Cordova Airport (MDE)

You can book a direct flight from Medellin to Santo Domingo leaving from Medellin Jose Maria Cordova Airport (MDE). Begin your trip at MDE and end it at Santo Domingo Las Americas Airport (SDQ).
Secure your Medellin to Santo Domingo plane tickets with Arajet. This airline is a top pick for direct flights from MDE.
Stopovers are the perfect opportunity to break up your trip — and perhaps even visit a new city. When searching for Medellin to Santo Domingo flights leaving from Medellin Jose Maria Cordova Airport, deselect the 'Direct flights only' box to see where you can visit along the way. Consider one of these popular options:
- Bogota Airport (BOG)
- Cartagena Airport (CTG)
- Caracas Airport (CCS)
The journey from central Medellin to MDE takes about 1 hour 15 minutes on public transport. If you ride-share, drive or get a taxi, you'll cover the 18 kilometres in 45 minutes or so, depending on traffic conditions.
Planning to catch an early flight from Medellin to Santo Domingo? Avoid the stress of rushing to the airport (and get some extra shut-eye) by choosing one of these hotels near Medellin Jose Maria Cordova Airport:
Of the departures from Medellin Jose Maria Cordova Airport, 76% touch down on time at their destination.

Arriving in Santo Domingo

Santo Domingo Las Americas Airport (SDQ)

Santo Domingo Las Americas Airport (SDQ) to central Santo Domingo takes around 35 minutes to reach by car. The centre is roughly 24 kilometres away.
When travelling on public transport, expect a journey time of about 1 hour 15 minutes.
The last thing you want is a long journey to your hotel if you're landing late on a flight from Medellin to Santo Domingo. Book one of these accommodation options near SDQ instead:
Travel at your own pace with a Santo Domingo Las Americas Airport rental car. Pick up your wheels from Final Homes, FlexWays or INFINITY RENT and venture far and wide through Santo Domingo and beyond.
Lock in the best rate by reserving your ride from Santo Domingo Las Americas Airport around one week ahead of your trip.

La Isabela International Airport (JBQ)

La Isabela International Airport (JBQ) is around 14 kilometres from central Santo Domingo. Once you've hopped off your flight from Medellin to Santo Domingo, it'll take you approximately 30 minutes to reach the heart of the city in a ride-share or taxi.
Travelling by public transport will take approximately 50 minutes.
Hang up the 'Do not disturb' sign and unwind at a hotel near JBQ. Here are a few options where you can take a load off after your flight from Medellin to Santo Domingo:
Why work around someone else's schedule? Grab a La Isabela International Airport rental car and steer your own course. Book your wheels here with FlexWays.
Generally, the sooner you book, the better the prices and vehicle selection. Secure your ride from JBQ as soon as you've confirmed your plans.

Best time to go to Santo Domingo

March is the quietest month for flights from Medellin to Santo Domingo, while July is the busiest. Figure out the ideal time to visit Santo Domingo based on whether you prefer a bustling atmosphere or a more laid-back vibe.
Book a Medellin to Santo Domingo ticket departing in September if you want to experience the city during its warmest month. You can expect temperatures in Santo Domingo to range from 23ºC (73ºF) to 33ºC (91ºF).
If you want to travel in cooler conditions, look for a cheap flight from Medellin to Santo Domingo in February when temperatures average between 19ºC (66ºF) and 29ºC (84ºF).

More about Santo Domingo

Start your Santo Domingo trip right by choosing the ideal place to stay. As soon as you've booked your flight from Medellin to Santo Domingo, browse our range of hotels including:
Alcazar de Colon and Nacional Botanical Garden are a couple of big attractions to add to your Santo Domingo travel itinerary. Keep the sightseeing going at Fortress of Columbus.

Explore more of the Dominican Republic

Santo Domingo will leave a lasting impression, but there are so many other corners of the Dominican Republic you'll want to see. About 2 kilometres northeast of Santo Domingo, a trip to Santo Domingo Este will keep your itinerary packed. Don't miss top attractions like Lago los tres ojos, Dominican Republic National Aquarium and La Cueva del Eden.
Around 64 kilometres east of Santo Domingo, San Pedro de Macorís is another essential stop in the Dominican Republic. Get a taste of what this destination has to offer at Pedro Mir Ecological Park, San Pedro de Macoris Boardwalk and Centro Cultural Macorisano.