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Cheap Flights from Knoxville (TYS) to Syracuse (SYR)

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Flight deals from Knoxville to Syracuse

Looking for a cheap last-minute deal or the best return flight from Knoxville to Syracuse? Find the lowest prices on one-way and return tickets right here.
Syracuse.$385 per passenger.Departing Tue, 21 Oct, returning Sun, 26 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from Knoxville on Tue, 21 Oct, arriving in Syracuse.Inbound indirect flight with Delta, departs from Syracuse on Sun, 26 Oct, arriving in Knoxville.Price includes taxes and charges.From $385, select.
Syracuse.$387 per passenger.Departing Fri, 1 Aug, returning Fri, 8 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Knoxville on Fri, 1 Aug, arriving in Syracuse.Inbound indirect flight with Delta, departs from Syracuse on Fri, 8 Aug, arriving in Knoxville.Price includes taxes and charges.From $387, select.
Syracuse.$416 per passenger.Departing Fri, 4 Jul, returning Tue, 8 Jul.Return flight with Delta.Outbound indirect flight with Delta, departs from Knoxville on Fri, 4 Jul, arriving in Syracuse.Inbound indirect flight with Delta, departs from Syracuse on Tue, 8 Jul, arriving in Knoxville.Price includes taxes and charges.From $416, select.

Find the cheapest month to fly from Knoxville to Syracuse

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Syracuse flights are currently cheapest in October.
Jun
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Jul
from $416
Aug
from $387
Sep
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Oct
from $385
Nov
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Dec
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Jan
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Feb
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Mar
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May
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Knoxville to Syracuse: Alternative routes

Compare routes from Knoxville to Syracuse below. You may find an airport to fly into that's cheaper, faster, or easier than Syracuse.

Knoxville to Syracuse: Flight information

The things to know before you go.
Cheapest flight found$385
Cheapest month to flyOctober

Finding cheap flights from Knoxville to Syracuse: Frequently asked questions

The best price we found for a return flight from Knoxville to Syracuse is $385. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to Syracuse. But we found flights with one or more stops from $385.
As of June 2025, there are no flights flying from Knoxville to Syracuse.
The cheapest month to fly from Knoxville to Syracuse is usually June 2025.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Syracuse Airport on Tuesday, 21 October 2025.
No airlines currently offer direct flights between Knoxville Airport and Syracuse Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Syracuse but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Syracuse is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Delta offers the cheapest flight tickets to Syracuse.

Travelling from McGhee Tyson Airport (TYS) to Hancock International Airport (SYR): what you need to know

  • Give yourself enough time to make your TYS to SYR flight. As a general rule, arrive two hours before international departures and an hour ahead for domestic flights.

  • During popular months such as July, it's a good idea to get to the airport even earlier. Plan to arrive two hours before a domestic departure and four hours ahead for an international flight when you travel during a peak period in general.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to Hancock International Airport (SYR)

  • Right now, $493 is the cheapest price we've seen for a one-way McGhee Tyson Airport to Hancock International Airport flight. The best price for a return plane ticket is $385. Keep in mind that fares can change due to demand when booking.

  • To pick up cheap tickets from TYS to SYR, book early. Airlines generally offer the most competitive fares when flights are first released.

  • The 'Whole month' tool shows you the cheapest flights from McGhee Tyson Airport to Hancock International Airport across every month. It's a good way to snap up a bargain if your trip dates aren't set in stone.

  • There's no need to check every day to see if fares have gone down when you create a Price Alert. We'll send you an update the moment there's a new deal on cheap flights from TYS to SYR.

  • Tailor your trip using filters. Choose your departure and arrival times, total journey duration and airlines. You can also sort the results by 'Best,' 'Cheapest' or 'Fastest' flights from McGhee Tyson Airport to Hancock International Airport.

Handy information about McGhee Tyson Airport (TYS)

  • TYS is located at 2055 Alcoa Highway.

  • Of the departures from McGhee Tyson Airport, 78.98% arrive as scheduled at their destination.

  • McGhee Tyson Airport is around 23 kilometres from central Knoxville. If you're catching a cab, ride-sharing or driving from the centre, it'll take you 20 minutes or so to arrive, depending on the traffic.

  • Get your travels off to a leisurely start by staying near TYS. Whether you have an early flight from McGhee Tyson Airport to Hancock International Airport or just don't like being rushed, these hotels are the answer:

Arriving at Hancock International Airport (SYR)

Getting from Hancock International Airport (SYR) to central Syracuse

  • SYR is located at City Hall.

  • From Hancock International Airport, Syracuse is approximately 18 kilometres away. It takes around 25 minutes to reach the centre by car.

  • It'll take around 1 hour 10 minutes if you're using public transport.

When to fly to Hancock International Airport (SYR)

  • The quietest month for a flight from McGhee Tyson Airport to Hancock International Airport is February, while July is the busiest. Choose the best time to visit Syracuse based on whether you prefer a faster pace or a more relaxed vibe.

  • The warmest month in Syracuse is July, with temperatures ranging between 14ºC (57ºF) and 28ºC (82ºF). Lock in your flights from McGhee Tyson Airport to Hancock International Airport in this month if this is the type of weather you enjoy.

  • For cooler conditions, look for a cheap ticket from TYS to SYR in January. Temperatures average between -12ºC (10ºF) and 3ºC (37ºF) then.

Explore more of United States

  • You've done Syracuse, now it's time to discover other corners of United States. Travel around 322 kilometres south-east to New York to tick off its leading sights. From Statue of Liberty to Central Park and Empire State Building, you'll have a packed itinerary ahead.

  • If you're looking to explore another side of United States, consider Philadelphia, about 354 kilometres south of Syracuse. Liberty Bell, Independence Hall and Philadelphia Museum of Art are key reasons to visit.

Plan the rest of your trip from Knoxville to Syracuse

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.