Cheap Flights from Knoxville (TYS) to Santa Ana (SNA)

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      Travellers and cabin class, 1 Adult, Economy

      Compare Knoxville to Santa Ana John Wayne flight deals

      Find the cheapest month or even day of the year to fly to Santa Ana John Wayne

      Book the best Santa Ana John Wayne fare with no extra fees

      Flight deals from Knoxville to Santa Ana John Wayne

      Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Santa Ana John Wayne Airport? If you want to travel next month, return fares start from $615. Find the lowest prices on one-way and return tickets right here.

      Find the cheapest month to fly from Knoxville to Santa Ana John Wayne

      We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Santa Ana John Wayne flights are currently cheapest in January.

      Knoxville to Santa Ana: Flight information

      The things to know before you go.
      Cheapest flight found$505
      Cheapest month to flyJanuary

      Finding cheap flights from Knoxville to Santa Ana John Wayne: Frequently asked questions

      The best price we found for a return flight from Knoxville to Santa Ana John Wayne is $505. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      Currently, there are no airlines that fly direct from Knoxville to Santa Ana John Wayne. But we found flights with one or more stops from $505.
      As of September 2026, there are no flights flying from Knoxville to Santa Ana John Wayne.
      The cheapest month to fly from Knoxville to Santa Ana John Wayne is usually January.
      After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Santa Ana John Wayne Airport on Wednesday, 6 January 2027.
      No airlines currently offer direct flights between Knoxville Airport and Santa Ana John Wayne Airport. Most routes have one or more stops.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santa Ana John Wayne but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santa Ana is around 40 days in advance, so don’t leave your flight to the last minute.

      Currently, Southwest Airlines offers the cheapest flight tickets to Santa Ana John Wayne.

      Flying from Knoxville Airport (TYS) to Santa Ana John Wayne Airport (SNA): what you need to know

      • The timezone in Santa Ana is UTC-8, which is three hours behind Knoxville.

      • Leave enough time to catch your TYS to SNA flight. Generally, it's best to arrive at least two hours before international departures and an hour ahead for domestic flights.

      • During popular months like October, it's best to get to the airport earlier. Plan to arrive two hours before a domestic departure and four hours ahead for international flights whenever you're flying during peak periods in general.

      How to find the cheapest flights from Knoxville Airport (TYS) to Santa Ana John Wayne Airport (SNA)

      • The lowest price we've found for a one-way Knoxville Airport to Santa Ana John Wayne Airport flight is $204. A return fare is currently $505. Depending on the availability when you book, these fares could change.

      • Don't wait until the last minute. You're more likely to find cheap tickets from TYS to SNA if you book early. Airlines often have some great early bird deals.

      • Getting cheap flights from Knoxville Airport to Santa Ana John Wayne Airport is easier if you can be flexible with your trip dates. Use the 'Whole month' search function to see the lowest fares throughout the month and land a great deal.

      • You won't have to check back in every day to see if fares have dropped when you set up a Price Alert. We'll update you as soon as there's a change in price on cheap flights from TYS to SNA.

      • Tailor your flights using filters. Pick your preferred arrival and departure times, airlines and total journey duration. You can also sort results by 'Best,' 'Cheapest' or 'Fastest' flights from Knoxville Airport to Santa Ana John Wayne Airport.

      Handy information about Knoxville Airport (TYS)

      • TYS is located at 2055 Alcoa Highway.

      • When it comes to the on-time performance of Knoxville Airport, 76% of flights arrive within the expected timeframe.

      • Knoxville Airport is about 24 kilometres from central Knoxville. If you're driving, ride-sharing or catching a taxi from the centre, it'll take you 25 minutes or so to get there, depending on the traffic.

      • The trip on public transport usually takes 50 minutes.

      • Looking for a handy hotel close to TYS? If you're catching an early flight from Knoxville Airport to Santa Ana John Wayne Airport, these stays will have you moments from your departure lounge:

      Arriving at Santa Ana John Wayne Airport (SNA)

      When to fly to Santa Ana John Wayne Airport (SNA)

      • July is the busiest month for flights from Knoxville Airport to Santa Ana John Wayne Airport. To escape the crowds, go to Santa Ana in March.

      • Lock in your flight from Knoxville Airport to Santa Ana John Wayne Airport for August if you'd like to go to Santa Ana during its warmest month. Expect temperatures of between 16ºC (61ºF) and 32ºC (90ºF).

      • January sees average temperatures of between 6ºC (43ºF) and 22ºC (72ºF). Look for cheap tickets from TYS to SNA sometime then if you like cooler conditions.

      Explore more of the United States

      • Santa Ana has its own special appeal, but there are so many other parts of the United States just waiting to be explored. Around 48 kilometres north-west of Santa Ana, a trip to Los Angeles will keep your itinerary packed. Start with leading attractions like Hollywood Sign, Universal Studios Hollywood and Hollywood Bowl.

      • Around 129 kilometres south-east of Santa Ana, San Diego is another essential stop in the United States. No visit is complete without checking out San Diego Zoo, San Diego Balboa Park and USS Midway Museum.

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.