Cheap Flights from Knoxville (TYS) to Buffalo (BUF)

Compare Knoxville to Buffalo Niagara flight deals

Find the cheapest month or even day of the year to fly to Buffalo Niagara

Book the best Buffalo Niagara fare with no extra fees

Flight deals from Knoxville to Buffalo Niagara

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Buffalo Niagara Airport? If you want to travel next month, return fares start from $461. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to Buffalo Niagara

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Buffalo Niagara flights are currently cheapest in August.

Knoxville to Buffalo Niagara: Alternative routes

Compare routes from Knoxville to Buffalo below. You may find an airport to fly into that's cheaper, faster, or easier than Buffalo Niagara.

Knoxville to Buffalo: Flight information

The things to know before you go.
Cheapest flight found$461
Cheapest month to flyAugust

Finding cheap flights from Knoxville to Buffalo Niagara: Frequently asked questions

The best price we found for a return flight from Knoxville to Buffalo Niagara is $461. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to Buffalo Niagara. But we found flights with one or more stops from $461.
As of July 2026, there are no flights flying from Knoxville to Buffalo Niagara.
The cheapest month to fly from Knoxville to Buffalo Niagara is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Buffalo Niagara Airport on Monday, 24 August 2026.
No airlines currently offer direct flights between Knoxville Airport and Buffalo Niagara Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Buffalo Niagara but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Buffalo is around 40 days in advance, so don’t leave your flight to the last minute.

Currently, Delta offers the cheapest flight tickets to Buffalo Niagara.

Flying from Knoxville Airport (TYS) to Buffalo Niagara Airport (BUF): what you need to know

  • Leave enough time to catch your TYS to BUF flight. Generally, it's best to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • During popular months such as October, it's best to get to the airport earlier. Plan to arrive two hours before a domestic departure and four hours ahead of international flights when you travel during a high season in general.

How to find the cheapest flights from Knoxville Airport (TYS) to Buffalo Niagara Airport (BUF)

  • The cheapest price we've found for a one-way Knoxville Airport to Buffalo Niagara Airport flight is $201. A round-trip ticket right now is $461. Depending on the availability when you book, these fares may change.

  • To find cheap tickets from TYS to BUF, book as early as you can. Airlines tend to offer their best fares when flights are first made available.

  • Getting cheap flights from Knoxville Airport to Buffalo Niagara Airport is more likely if you can be flexible with your travel plans. Use the 'Whole month' search function to see the lowest prices throughout the month and score a great deal.

  • Picking up cheap flights from TYS to BUF is a breeze with Price Alerts. All you need to do is set up one of these automatic alerts and we'll notify you when fares go down.

  • Tailor your flights with filters. Choose your preferred arrival and departure times, airlines and total journey duration. You can also sort results by 'Cheapest,' 'Best' or 'Fastest' flights from Knoxville Airport to Buffalo Niagara Airport.

Handy information about Knoxville Airport (TYS)

  • TYS's address is 2055 Alcoa Highway.

  • 76% of flights that take off from Knoxville Airport touch down at their destination on time.

  • Central Knoxville to Knoxville Airport is around 24 kilometres. Depending on traffic, it'll take you about 25 minutes to get there if you're ride-sharing, catching a taxi or driving.

  • Expect a journey time of around 50 minutes when using public transport.

  • Get your holiday off to a relaxed start by staying near TYS. Whether you've booked an early flight from Knoxville Airport to Buffalo Niagara Airport or want to avoid feeling rushed, these stays have you covered:

Arriving at Buffalo Niagara Airport (BUF)

  • If you have a late Knoxville Airport to Buffalo Niagara Airport flight, few things beat the convenience of being near the terminal. Grab your bags from the carousel and then be showered and sleeping shortly after at one of these accommodation options near BUF:

  • Say yes to new adventures by picking up a Buffalo Niagara Airport rental car. Grab a set of wheels from Dollar, Hertz or Budget and experience the lesser-explored corners of Buffalo and beyond.

  • Reserving your vehicle from Buffalo Niagara Airport around two weeks in advance can help you get the best possible rate.

When to fly to Buffalo Niagara Airport (BUF)

  • It's time to plan your trip dates for your flight from Knoxville Airport to Buffalo Niagara Airport. August is the most popular month to head to Buffalo. If you want a more relaxed vibe, go in March.

  • The warmest month in Buffalo is July, with temperatures ranging between 15ºC (59ºF) and 29ºC (84ºF). Book your flights from Knoxville Airport to Buffalo Niagara Airport in this month if this is the type of weather you enjoy.

  • If you want cooler conditions, search for a cheap ticket from TYS to BUF in January. Average temperatures are between -10ºC (14ºF) and 2ºC (36ºF) then.

Explore more of the United States

  • Buffalo has loads to offer, but there are so many other corners of the United States you'll want to see. About 467 kilometres south-east of Buffalo, a trip to New York will keep your itinerary packed. Start with leading attractions like Central Park, Statue of Liberty and Metropolitan Museum of Art.

  • Around 451 kilometres south-east of Buffalo, Philadelphia is another favourite stop in the United States. Experience major highlights starting with Independence Hall, Liberty Bell and Philadelphia Museum of Art.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.