Cheap Flights from St Louis (STL) to Des Moines (DSM)

Compare St Louis to Des Moines flight deals

Find the cheapest month or even day of the year to fly to Des Moines

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Flight deals from St Louis to Des Moines

Looking for a cheap last-minute deal or the best return flight from St Louis Airport to Des Moines Airport? If you want to travel next month, return fares start from $302. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from St Louis to Des Moines

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like St Louis to Des Moines flights are currently cheapest in August.

St Louis to Des Moines: Alternative routes

Compare routes from St Louis to Des Moines below. You may find an airport to fly into that's cheaper, faster, or easier than Des Moines.

St Louis to Des Moines: Flight information

The things to know before you go.
Cheapest flight found$302
Cheapest month to flyAugust

Finding cheap flights from St Louis to Des Moines: Frequently asked questions

The best price we found for a return flight from St Louis to Des Moines is $302. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from St Louis to Des Moines. But we found flights with one or more stops from $302.
As of July 2026, there are no flights flying from St Louis to Des Moines.
The cheapest month to fly from St Louis to Des Moines is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from St Louis Airport to Des Moines Airport on Tuesday, 4 August 2026.
No airlines currently offer direct flights between St Louis Airport and Des Moines Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Des Moines but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Des Moines is around 40 days in advance, so don’t leave your flight to the last minute.

Currently, Delta offers the cheapest flight tickets to Des Moines.

Travelling from St Louis Airport (STL) to Des Moines Airport (DSM): what you need to know

  • Around 1 hour 10 minutes is how long you can expect to be travelling on a direct flight from St Louis Airport to Des Moines Airport.

  • Your STL to DSM flight won't wait if you're late, so show up at the airport on time. Arrive up to one hour in advance for domestic flights and two hours ahead for international travel.

  • Be prepared for bigger queues in popular months like July. Arriving up to four hours ahead of an international flight and two hours for a domestic departure is a wise move.

  • Southwest Airlines is your ticket to exploring Des Moines (and perhaps some other exciting corners of the United States!). Browse the direct flights from St Louis Airport to Des Moines Airport offered by this popular carrier.

  • The airline with the highest number of bookings on this route is Southwest Airlines.

  • Southwest Airlines is the most punctual carrier that offers STL to DSM flights, with 78.41% of its services landing on schedule.

  • Think about adding a stopover when booking your ticket from St Louis Airport to Des Moines Airport. Just deselect 'Direct flights only' to break up your trip, or even explore someplace new along the way. Here are some options between STL and DSM:

    • Chicago O'Hare International Airport

    • Detroit Wayne County Airport

    • Nashville Airport

How to find the cheapest flights from St Louis Airport (STL) to Des Moines Airport (DSM)

  • The cheapest price we've seen for a one-way St Louis Airport to Des Moines Airport flight is $150. A return ticket is currently $302. Depending on the availability when you book, these fares can change.

  • Get cheap tickets from STL to DSM by booking at least one month ahead. Based on our research, that's the sweet spot for picking up a bargain.

  • The cheapest month for flights from St Louis Airport to Des Moines Airport is June. Use the 'Whole month' tool to find the lowest prices if you have a flexible schedule.

  • Spend less time searching for cheap flights from STL to DSM by setting up a Price Alert. You'll receive an email or push notification on the app when a new discounted fare appears.

  • Tailor your flights using filters. Select your ideal arrival and departure times, total journey duration and airlines. You can also sort the results by 'Fastest,' 'Best' or 'Cheapest' flights from St Louis Airport to Des Moines Airport.

Handy information about St Louis Airport (STL)

Arriving at Des Moines Airport (DSM)

When to fly to Des Moines Airport (DSM)

  • The quietest month for a flight from St Louis Airport to Des Moines Airport is March, while August is the most popular. Pick the best time to visit Des Moines based on whether you prefer a bustling atmosphere or a more laid-back vibe.

  • Lock in your flight from St Louis Airport to Des Moines Airport for July if you want to visit Des Moines during its warmest month. You can expect temperatures of between 15ºC (59ºF) and 31ºC (88ºF).

  • If you'd rather travel in cooler conditions, look for a cheap ticket from STL to DSM in January. Temperatures average between -13ºC (9ºF) and 2ºC (36ºF) then.

Explore more of the United States

  • Des Moines has its own special appeal, but there are so many other parts of the United States just waiting to be discovered. Around 499 kilometres east of Des Moines, a visit to Chicago will keep you on the go. Don't miss top attractions like Millennium Park, Art Institute of Chicago and Willis Tower.

  • Milwaukee is another must-experience destination in the United States and is around 499 kilometres east of Des Moines. No journey is complete without dropping by Richards Duplex Apartments by Frank Lloyd Wright, Miller Park and Milwaukee County Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.