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Cheap Flights from Greenville (GSP) to Des Moines (DSM)

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Flight deals from Greenville-Spartanburg to Des Moines

Looking for a cheap last-minute deal or the best return flight from Greenville-Spartanburg to Des Moines? Find the lowest prices on one-way and return tickets right here.
Des Moines.$383 per passenger.Departing Thu, 28 Aug, returning Wed, 3 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Greenville-Spartanburg on Thu, 28 Aug, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 3 Sep, arriving in Greenville-Spartanburg.Price includes taxes and charges.From $383, select.
Des Moines.$454 per passenger.Departing Wed, 13 Aug, returning Sun, 17 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Greenville-Spartanburg on Wed, 13 Aug, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Sun, 17 Aug, arriving in Greenville-Spartanburg.Price includes taxes and charges.From $454, select.
Des Moines.$659 per passenger.Departing Thu, 17 Jul, returning Mon, 21 Jul.Return flight with United.Outbound indirect flight with United, departs from Greenville-Spartanburg on Thu, 17 Jul, arriving in Des Moines.Inbound indirect flight with United, departs from Des Moines on Mon, 21 Jul, arriving in Greenville-Spartanburg.Price includes taxes and charges.From $659, select.
Des Moines.$1,090 per passenger.Departing Wed, 26 Nov, returning Sun, 30 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Greenville-Spartanburg on Wed, 26 Nov, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Sun, 30 Nov, arriving in Greenville-Spartanburg.Price includes taxes and charges.From $1,090, select.

Find the cheapest month to fly from Greenville-Spartanburg to Des Moines

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Greenville-Spartanburg to Des Moines flights are currently cheapest in August.
Jul
from $659
Aug
from $454
Sep
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Oct
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Nov
from $1,090
Dec
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Jan
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Apr
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Greenville-Spartanburg to Des Moines: Alternative routes

Compare routes from Greenville-Spartanburg to Des Moines below. You may find an airport to fly into that's cheaper, faster, or easier than Des Moines.

Greenville to Des Moines: Flight information

The things to know before you go.
Cheapest flight found$383
Cheapest month to flyAugust

Finding cheap flights from Greenville-Spartanburg to Des Moines: Frequently asked questions

The best price we found for a return flight from Greenville-Spartanburg to Des Moines is $383. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Greenville-Spartanburg to Des Moines. But we found flights with one or more stops from $383.
As of July 2025, there are no flights flying from Greenville-Spartanburg to Des Moines.
The cheapest month to fly from Greenville-Spartanburg to Des Moines is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Greenville-Spartanburg Airport to Des Moines Airport on Thursday, 28 August 2025.
No airlines currently offer direct flights between Greenville-Spartanburg Airport and Des Moines Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Des Moines but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Des Moines is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Delta offers the cheapest flight tickets to Des Moines.

Travelling from Greenville-Spartanburg International Airport (GSP) to Des Moines International Airport (DSM): what you need to know

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules to live by. Be at the airport on time to catch your GSP to DSM flight.

  • Travelling during a peak time like August? School holidays and other high seasons can result in longer queues at airport checkpoints. Be extra cautious and get there up to four hours ahead of an international flight and two hours before domestic departures.

  • Think about adding a stopover when booking your ticket from Greenville-Spartanburg International Airport to Des Moines International Airport. Just uncheck 'Direct flights only' to break up your trip, or maybe even explore a new city along the way. Here's where you can stop between GSP and DSM:

    • O'Hare International Airport

    • Hartsfield-Jackson Atlanta International Airport

    • Charlotte Douglas International Airport

How to find the cheapest flights from Greenville-Spartanburg International Airport (GSP) to Des Moines International Airport (DSM)

  • The lowest price we've seen for a one-way Greenville-Spartanburg International Airport to Des Moines International Airport flight is $181. A return plane ticket right now is $383. Depending on the availability when you book, these fares may change.

  • Don't leave everything to the last minute. You're more likely to get cheap tickets from GSP to DSM if you book in advance. Airlines often have some terrific early bird discounts.

  • The 'Whole month' search tool shows you the cheapest flights from Greenville-Spartanburg International Airport to Des Moines International Airport across each month. It's an easy way to find a bargain if your travel dates are flexible.

  • Stay on top of deals for cheap flights from GSP to DSM by creating a Price Alert. We'll send you an email or push notification on the app when a new low fare is offered.

  • Secure the right flight for you with the help of the filters. To see the 'Cheapest,' 'Fastest' or 'Best' flights from Greenville-Spartanburg International Airport to Des Moines International Airport, use the 'Sort by' function. You can also filter results by airline, arrival and departure times, and journey duration.

Handy information about Greenville-Spartanburg International Airport (GSP)

  • GSP's address is 2000 GPS Drive, Suite 1.

  • When it comes to the on-time performance of Greenville-Spartanburg International Airport, 79.7% of flights arrive within the scheduled timeframe.

  • To reach Greenville-Spartanburg International Airport from central Greenville, it'll take about 20 minutes if you're planning to drive. This depends on traffic, however. It's approximately 27 kilometres from the airport to the city centre.

  • Have an early flight from Greenville-Spartanburg International Airport to Des Moines International Airport? Avoid the last-minute rush to the airport (and catch some extra z's) by picking one of these hotels close to GSP:

Arriving at Des Moines International Airport (DSM)

Getting from Des Moines International Airport (DSM) to central Des Moines

  • You'll find DSM at 5800 Fleur Drive, Suite 201.

  • Des Moines International Airport to the centre of Des Moines has a drive time of around 15 minutes. It's approximately 10 kilometres away.

  • If you're travelling by public transport, expect a journey of about 45 minutes.

When to fly to Des Moines International Airport (DSM)

  • The quietest month for a flight from Greenville-Spartanburg International Airport to Des Moines International Airport is April, while July is the busiest. Pick the best time to go to Des Moines based on whether you prefer a faster pace or a more relaxed vibe.

  • Lock in your flight from Greenville-Spartanburg International Airport to Des Moines International Airport for July if you'd like to explore Des Moines during its warmest month. Expect temperatures of between 15ºC (59ºF) and 31ºC (88ºF).

  • If you want to travel in cooler conditions, search for a cheap ticket from GSP to DSM in January. Temperatures average between -13ºC (9ºF) and 2ºC (36ºF) then.

Explore more of United States

  • You've done Des Moines, now it's time to explore other parts of United States. Travel about 499 kilometres east to Chicago to check off its leading attractions. From Millennium Park to Art Institute of Chicago and LandShark Beer Garden at Navy Pier, you'll have a packed itinerary ahead.

  • Around 499 kilometres east of Des Moines, Milwaukee is another essential stop in United States. Experience this destination's highlights firsthand at Miller Park, Pabst Mansion and Milwaukee Public Museum.

Plan the rest of your trip from Greenville to Des Moines

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.