Flights from Des Moines Airport to South Carolina

Flight deals from Des Moines Airport to South Carolina

Looking for cheap tickets from Des Moines Airport to South Carolina, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Charleston.$280 per passenger.Departing Fri, 27 Feb.One-way flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Fri, 27 Feb, arriving in Charleston.Price includes taxes and charges.From $280, select.

Columbia.$363 per passenger.Departing Mon, 9 Mar.One-way flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Mon, 9 Mar, arriving in Columbia Metropolitan.Price includes taxes and charges.From $363, select.

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Flying from Des Moines Airport to South Carolina

Arm yourself with these facts on the fly.

Cheapest flight found	$280
Cheapest month to fly	February

How to find cheap flights from Des Moines Airport to South Carolina

We've compared the best online travel agents and flight providers on the internet to find the cheapest plane tickets from Des Moines Airport to South Carolina. Other savvy travellers recently found return flights from $400 and one-way tickets from $280. Ready to join them? Here are a few tips to help you do it the smart way.

Fly in March

The cheapest time to fly from Des Moines Airport to South Carolina is currently March.

Flex your dates for the best rates

If you’re flexible on your departure dates, you can use Skyscanner's whole month tool to find the cheapest day of the year to fly from Des Moines Airport to anywhere you choose in South Carolina.

Watch as fares rise and fall

With Price Alerts, we'll let you know when flight prices from Des Moines Airport to your chosen airport in South Carolina go up or down so you can book when the time is just right.

Relax – these are fee-free flight tickets

With us, there are no added fees – the South Carolina Airport to South Carolina flight price you see when you search with us is what you pay to the provider.

Frequently asked questions

Are there any direct flights from Des Moines Airport to South Carolina?

There are currently no direct flights from Des Moines Airport to South Carolina, but we've found some other routes to United States – check them out now.

What is the average price of a flight from Des Moines Airport to South Carolina?

We looked at all of the upcoming return flights from Des Moines Airport to South Carolina we could find over the next 12 months. It looks like $400 is the best price. This is good, compared to the average South Carolina ticket price of $527.

What is the cheapest month to fly from Des Moines Airport to South Carolina?

The cheapest month to fly from Des Moines Airport to Columbia Metropolitan Airport is currently March.
The cheapest month to fly from Des Moines Airport to Charleston Airport is currently May.
The cheapest month to fly from Des Moines Airport to Greenville-Spartanburg Airport is currently February.
And the cheapest month to fly from Des Moines Airport to Hilton Head Airport is usually May.

Which upcoming date is cheapest to fly from Des Moines Airport to South Carolina on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Des Moines Airport to South Carolina on Sunday, 8 March 2026.

If I'm flying from Des Moines Airport, where in South Carolina is cheapest to fly into?

If you're flying from Des Moines, the cheapest city in South Carolina to fly into is Columbia. The cheapest airport serving Columbia at the moment is Columbia Metropolitan.