Cheap Flights from Des Moines (DSM) to St Louis (STL)

Compare Des Moines to St Louis flight deals

Find the cheapest month or even day of the year to fly to St Louis

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Flight deals from Des Moines to St Louis

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to St Louis Airport? If you want to travel next month, return fares start from $341. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Des Moines to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to St Louis flights are currently cheapest in August.

Des Moines to St Louis: Alternative routes

Compare routes from Des Moines to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

Des Moines to St Louis: Flight information

The things to know before you go.
Cheapest flight found$304
Cheapest month to flyAugust

Finding cheap flights from Des Moines to St Louis: Frequently asked questions

The best price we found for a return flight from Des Moines to St Louis is $304. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to St Louis. But we found flights with one or more stops from $304.
As of June 2026, there are no flights flying from Des Moines to St Louis.
The cheapest month to fly from Des Moines to St Louis is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to St Louis Airport on Saturday, 8 August 2026.
No airlines currently offer direct flights between Des Moines Airport and St Louis Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.

Currently, United offers the cheapest flight tickets to St Louis.

Flying from Des Moines Airport (DSM) to St Louis Airport (STL): what you need to know

  • Jump on a direct flight from Des Moines Airport to St Louis Airport and you'll be travelling for an average of 1 hour 15 minutes.

  • Des Moines and St Louis follow the same timezone, UTC-6.

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules to live by. Show up at the airport on time to catch your DSM to STL flight.

  • During popular months like August, it's a good idea to get to the airport earlier than normal. Arrive two hours before domestic departures and four hours ahead of an international flight whenever you're travelling during peak periods in general.

  • Southwest Airlines is your ticket to exploring St Louis (and perhaps some other exciting parts of the United States!). Check out the direct flights from Des Moines Airport to St Louis Airport offered by this popular airline.

  • The airline with the highest number of bookings on this route is Southwest Airlines.

  • Southwest Airlines leads the way as the most punctual carrier for DSM to STL flights, with 85.96% of its services landing on schedule.

  • If you'd like to include a stop along the way, simply uncheck 'Direct flights only' when searching for your ticket from Des Moines Airport to St Louis Airport. Here are the most popular stopovers between DSM and STL:

    • Chicago O'Hare International Airport

    • Detroit Wayne County Airport

    • Minneapolis St Paul Airport

How to find the cheapest flights from Des Moines Airport (DSM) to St Louis Airport (STL)

  • Right now, $156 is the lowest price we've found for a one-way Des Moines Airport to St Louis Airport flight. The best price for a return ticket is $304. Remember that fares could change due to availability when booking.

  • Book four months before flying. After crunching the numbers on our calendar, this is how far you'll want to book ahead to find cheap tickets from DSM to STL.

  • The cheapest month for flights from Des Moines Airport to St Louis Airport is September. Use the 'Whole month' tool to see the lowest airfares if you have a flexible schedule.

  • Snapping up cheap flights from DSM to STL is easy with Price Alerts. Simply set up one of these automatic alerts and we'll get in touch as soon as a new discounted fare appears.

  • Tailor your trip using filters. Pick your ideal arrival and departure times, airlines and total journey duration. You can also sort the results by 'Best,' 'Cheapest' or 'Fastest' flights from Des Moines Airport to St Louis Airport.

Handy information about Des Moines Airport (DSM)

  • DSM is located at 5800 Fleur Drive, Suite 201.

  • When it comes to the on-time performance of Des Moines Airport, 77% of flights stick to their scheduled arrival time.

  • Central Des Moines to Des Moines Airport is around 11 kilometres. Depending on traffic, it'll take about 15 minutes to get there if you're ride-sharing, catching a taxi or driving.

  • The trip on public transport usually takes 30 minutes.

  • Taking an early flight from Des Moines Airport to St Louis Airport? Avoid the last-minute rush to the terminal (and get some extra shut-eye) by choosing one of these stays near DSM:

Arriving at St Louis Airport (STL)

Getting from St Louis Airport (STL) to central St Louis

  • You'll find STL at 10701 Lambert International Blvd..

  • From St Louis Airport, St Louis is approximately 24 kilometres away. It takes around 25 minutes to drive to the centre.

  • Getting there on public transport takes about 30 minutes.

When to fly to St Louis Airport (STL)

  • July is the busiest month for flights from Des Moines Airport to St Louis Airport. To skip the crowds, travel to St Louis in March.

  • Before locking in your flight from Des Moines Airport to St Louis Airport, consider the kind of weather you enjoy. July is the warmest month in St Louis, with the temperature ranging from 17ºC (63ºF) to 33ºC (91ºF).

  • Search for cheap tickets from DSM to STL in January if you like cooler conditions. Temperatures are at their lowest then, ranging between -7ºC (19ºF) and 8ºC (46ºF) on average.

Explore more of the United States

  • St Louis has its own special appeal, but there are so many other parts of the United States you'll want to see. About 418 kilometres north-east of St Louis, a visit to Chicago will keep your itinerary busy. Don't miss top attractions like Millennium Park, Art Institute of Chicago and Willis Tower.

  • Indianapolis is another essential stop in the United States and is around 370 kilometres east of St Louis. No journey is complete without experiencing Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.