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Cheap Flights from Des Moines (DSM) to Prague (PRG)

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Flight deals from Des Moines to Prague

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to Prague Airport? If you want to travel next month, return fares start from $1,426. Find the lowest prices on one-way and return tickets right here.
Prague.$1,302 per passenger.Departing Tue, 28 Jul, returning Tue, 4 Aug.Return flight with Lufthansa.Outbound indirect flight with Lufthansa, departs from Des Moines on Tue, 28 Jul, arriving in Prague.Inbound indirect flight with Lufthansa, departs from Prague on Tue, 4 Aug, arriving in Des Moines.Price includes taxes and charges.From $1,302, select.
Prague.$1,426 per passenger.Departing Fri, 24 Jul, returning Fri, 31 Jul.Return flight with Lufthansa.Outbound indirect flight with Lufthansa, departs from Des Moines on Fri, 24 Jul, arriving in Prague.Inbound indirect flight with Lufthansa, departs from Prague on Fri, 31 Jul, arriving in Des Moines.Price includes taxes and charges.From $1,426, select.
Prague.$1,570 per passenger.Departing Sat, 1 Aug, returning Sat, 8 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 1 Aug, arriving in Prague.Inbound indirect flight with Delta, departs from Prague on Sat, 8 Aug, arriving in Des Moines.Price includes taxes and charges.From $1,570, select.
Prague.$1,758 per passenger.Departing Fri, 20 Nov, returning Sun, 22 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Fri, 20 Nov, arriving in Prague.Inbound indirect flight with Delta, departs from Prague on Sun, 22 Nov, arriving in Des Moines.Price includes taxes and charges.From $1,758, select.

Find the cheapest month to fly from Des Moines to Prague

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Prague flights are currently cheapest in July.
Jun
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Jul
from $1,426
Aug
from $1,570
Sep
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Oct
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Nov
from $1,758
Dec
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Jan
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Feb
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Mar
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Apr
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May
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Des Moines to Prague: Alternative routes

Compare routes from Des Moines to Prague below. You may find an airport to fly into that's cheaper, faster, or easier than Prague.

Prague

11km from central Prague
ClosestCheapest
from $1,302
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Des Moines to Prague: Flight information

The things to know before you go.
Cheapest flight found$1,302
Cheapest month to flyJuly

Finding cheap flights from Des Moines to Prague: Frequently asked questions

The best price we found for a return flight from Des Moines to Prague is $1,302. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Prague. But we found flights with one or more stops from $1,302.
As of June 2026, there are no flights flying from Des Moines to Prague.
The cheapest month to fly from Des Moines to Prague is usually July.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Prague Airport on Tuesday, 28 July 2026.
No airlines currently offer direct flights between Des Moines Airport and Prague Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Prague but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Prague is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Lufthansa offers the cheapest flight tickets to Prague.

Travelling from Des Moines Airport (DSM) to Prague Airport (PRG): what you need to know

  • Prague's timezone is UTC+1, which makes Prague seven hours ahead of Des Moines.

  • Give yourself enough time to catch your DSM to PRG flight. As a rule of thumb, arrive at least two hours before international departures and an hour ahead for domestic flights.

  • Flying during a peak time such as August? Major public holidays and other popular periods can lead to longer queues at check-in and security. Play it safe and arrive up to four hours before international flights and two hours before domestic departures.

How to find the cheapest flights from Des Moines Airport (DSM) to Prague Airport (PRG)

  • $523 is the lowest price for a one-way Des Moines Airport to Prague Airport flight. A return flight starts from $1,302. These fares can change based on availability.

  • To get your hands on cheap tickets from DSM to PRG, book ahead. Airlines tend to offer lower prices when flights are first released.

  • The 'Whole month' search function shows you the cheapest flights from Des Moines Airport to Prague Airport across every month. It's an easy way to snap up a bargain if your travel dates aren't set in stone.

  • Save time looking for cheap flights from DSM to PRG by setting up a Price Alert. You'll get an email or push notification on the app when a new discounted fare appears.

  • Discover the right flight for you with the help of the filters. To see the 'Fastest,' 'Best' or 'Cheapest' flights from Des Moines Airport to Prague Airport, use the 'Sort by' function. You can also filter by departure and arrival times, airline, and journey duration.

Handy information about Des Moines Airport (DSM)

  • The address for DSM is 5800 Fleur Drive, Suite 201.

  • 77% of flights that leave from Des Moines Airport make it to their destination on time.

  • To reach Des Moines Airport from central Des Moines, it'll take about 15 minutes by car. This depends on traffic, however. It's approximately 11 kilometres from the airport to the city centre.

  • Planning to take public transport? Expect a journey time of around 30 minutes.

  • Have an early flight from Des Moines Airport to Prague Airport? Avoid rushing to the airport (and sneak in some extra precious sleep) by picking one of these stays near DSM:

Arriving at Prague Airport (PRG)

Getting from Prague Airport (PRG) to central Prague

  • From Prague Airport, Prague is approximately 18 kilometres away. It takes around 25 minutes to reach the centre driving.

  • It'll take around 35 minutes if you're travelling by public transport.

When to fly to Prague Airport (PRG)

  • September is the busiest month for flights from Des Moines Airport to Prague Airport. To skip the crowds, go to Prague in March.

  • When booking your flight from Des Moines Airport to Prague Airport, consider the type of weather you like. August is the warmest month in Prague, with temperatures ranging from 12ºC (54ºF) to 27ºC (81ºF).

  • If you like travelling in cooler conditions, look for a cheap ticket from DSM to PRG in January. Average temperatures are between -8ºC (18ºF) and 5ºC (41ºF) then.

Explore more of Czechia

  • Brno is just one of the many cities in Czechia waiting to be discovered once you've seen Prague. Around 177 kilometres away to the south-east, well-known attractions include Tugendhat Villa, Botanicka Zahrada (Hortus Botanicus) and Špilberk Castle.

  • Ostrava is another well-known destination in Czechia and is around 274 kilometres east of Prague. No journey is complete without a visit to Landek, Landek Park and Dolní Vítkovice.

Plan the rest of your trip from Des Moines to Prague

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.