Cheap Flights from Des Moines to St Louis

Compare Des Moines to St Louis flight deals

Find the cheapest month or even day of the year to fly to St Louis

Book the best St Louis fare with no extra fees

Flight deals from Des Moines to St Louis

Looking for a cheap last-minute deal or the best return flight from Des Moines to St Louis? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Des Moines to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to St Louis flights are currently cheapest in November.

Direct flights from Des Moines to St Louis

Des Moines to St Louis: Alternative routes

Compare routes from Des Moines to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

Des Moines to St Louis: Flight information

The things to know before you go.
Cheapest flight found$270
Cheapest month to flyNovember
Average flight time1 hr, 11 mins
Most popular airlineSouthwest Airlines
Average flights per week16

Finding cheap flights from Des Moines to St Louis: Frequently asked questions

The best price we found for a return flight from Des Moines to St Louis is $270. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
1 hour and 11 minutes is the average flight time from Des Moines to St Louis.
Southwest Airlines flies direct from Des Moines to St Louis.
As of October 2024, there are 16 flights per week flying from Des Moines to St Louis.
The cheapest month to fly from Des Moines to St Louis is usually October 2024.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to St Louis Airport on Thursday, 28 November 2024.
Yes – the average flight time is 1 hour and 11 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Delta and Southwest Airlines offer the cheapest flight tickets to St Louis.

How to find cheap flights to St Louis from Des Moines

Looking for cheap tickets from Des Moines to St Louis? Here are a few tips on how to secure the best flight price and make your journey as smooth as possible.

  • Simply hit 'search'. From British Airways to international carriers like Emirates, we compare all major airlines along with the most popular online travel agents to find the cheapest plane tickets from Des Moines to St Louis. And with us there are no hidden fees - what you see is what you pay.
  • Compare flight deals to St Louis from Des Moines from over 1,000 providers. Then choose the cheapest or fastest plane tickets.
  • Flex your dates to find the best Des Moines-St Louis ticket prices. If you are flexible when it comes to your travel dates, use Skyscanner's 'Whole month' tool to find the cheapest month, and even day to fly to St Louis from Des Moines.
  • Set up a Price Alert. You can easily track the fare of your cheap Des Moines-St Louis flights by creating an alert. Whenever prices go down or up, you'll get an email or push notification to help make sure you get the best possible flight deal.
  • Fly without stops. Only interested in direct flights between Des Moines and St Louis? Make sure to tick 'Direct flights only' when performing a search. If there are direct flights available on the route, these will appear in the results.
  • Find the cheapest Business class flights from Des Moines and St Louis. We scour the internet for the best Business, Premium Economy and First Class flight fares to St Louis, too. Check the difference in price as you search – you might just chance upon a last-minute low fare. Note that not all cabin classes are available for every destination or airline.
  • Include nearby airports in your search. Widen your search for Des Moines to St Louis flight deals by selecting the "add nearby airports" option. This will allow you to see flight prices for all the nearest airports at your departure point and your destination and could help you save next time you travel.
  • Combine your flight to St Louis from Des Moines with hotels and car hire

    Once you've secured your cheap flight ticket from Des Moines to St Louis, discover the best prices and exclusive rates for hotels in St Louis or nearby. You can also compare hundreds of car hire companies in one go so that you get the best car hire price for your trip.


Prices shown on this page are estimated lowest prices only. Found in the last 45 days.