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Cheap Flights from Panama City (PTYA) to Santo Domingo (SDQA)

Compare Panama City to Santo Domingo flight deals

Find the cheapest month or even day of the year to fly to Santo Domingo

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Flight deals from Panama City to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Panama City to Santo Domingo? Find the lowest prices on one-way and return tickets right here.
Santo Domingo.$685 per passenger.Departing Sun, 19 Oct, returning Thu, 23 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 19 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 23 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $685, select.
Santo Domingo.$685 per passenger.Departing Wed, 10 Sep, returning Sun, 14 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 10 Sep, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sun, 14 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $685, select.
Santo Domingo.$685 per passenger.Departing Sat, 6 Sep, returning Fri, 31 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 6 Sep, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 31 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $685, select.
Santo Domingo.$687 per passenger.Departing Fri, 29 Aug, returning Tue, 16 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 29 Aug, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 16 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $687, select.
Santo Domingo.$687 per passenger.Departing Sun, 28 Sep, returning Tue, 28 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 28 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 28 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $687, select.
Santo Domingo.$687 per passenger.Departing Tue, 16 Sep, returning Sun, 21 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 16 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 21 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $687, select.
Santo Domingo.$687 per passenger.Departing Thu, 2 Oct, returning Tue, 7 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 2 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 7 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $687, select.
Santo Domingo.$688 per passenger.Departing Fri, 31 Oct, returning Tue, 4 Nov.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 31 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 4 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $688, select.

Find the cheapest month to fly from Panama City to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Santo Domingo flights are currently cheapest in September.
Aug
from $1,098
Sep
from $685
Oct
from $685
Nov
from $690
Dec
from $691
Jan
from $691
Feb
from $689
Mar
from $693
Apr
from $697
May
Find prices
Jun
Find prices
Jul
Find prices

Direct flights from Panama City to Santo Domingo

Alternative Panama City to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Panama City to Santo Domingo? You could fly into the following airports instead.

Panama City to Santo Domingo: Flight information

The things to know before you go.
Cheapest flight found$685
Cheapest month to flySeptember
Average flight time2 hrs, 29 mins
Most popular airlineCopa
Average flights per week59

Finding cheap flights from Panama City to Santo Domingo: Frequently asked questions

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.
The best price we found for a return flight from Panama City to Santo Domingo is $685. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 29 minutes is the average flight time from Panama City to Santo Domingo.
Copa, KLM and Air France fly direct from Panama City to Santo Domingo.
As of August 2025, there are 59 flights per week flying from Panama City to Santo Domingo.
The cheapest month to fly from Panama City to Santo Domingo is usually September.
If you're flying from Panama City, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from $685.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Santo Domingo on Wednesday, 10 September 2025.
Yes – the average flight time is 2 hours and 29 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.
In August, the average temperature is usually around 28°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.
The cheapest airline that flies to Santo Domingo is Avianca. And the cheapest airline that flies to Santo Domingo Las Americas Airport is Copa.

Flying from Panama City to Santo Domingo: what you need to know

  • There are a couple of main airports you can start your journey from in Panama City. Explore your options leaving from Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB) when searching for a flight from Panama City to Santo Domingo.

  • Las Americas International Airport (SDQ) and Dr. Joaquin Balaguer International Airport (JBQ) are Santo Domingo's major entry points.

  • The average time for a direct Panama City to Santo Domingo flight is 2 hours 30 minutes.

  • Santo Domingo is one hour ahead of Panama City and is in the UTC-4 timezone.

  • Tocumen International Airport (PTY) to Las Americas International Airport (SDQ) is the most popular route between these two cities. There are 29 departures a week to choose from. If you have things to do before leaving, the last flight from Panama City to Santo Domingo is with Copa Airlines at 22:13. Go for the first PTY to SDQ departure with Copa Airlines at 07:18 to fit in more activities on your first day in Santo Domingo.

  • For a stress-free journey, arrive at the airport two hours ahead of international flights and one hour before domestic departures. This will give you plenty of time to catch your Panama City to Santo Domingo flight.

  • You'll likely experience longer lines during popular months such as June. Arriving up to four hours ahead of international flights and two hours for domestic departures will give you plenty of time for security and boarding.

How to find the cheapest flights from Panama City to Santo Domingo

  • Book one month before you travel. Research into pricing trends suggests this is the ideal window for finding cheap Panama City to Santo Domingo flights.

  • Schedule your trip for April. That's the best month for scoring great bargains on plane tickets from Panama City to Santo Domingo. If your travel dates are not set in stone, use the 'Whole month' tool to find the lowest price across every month.

  • Getting a cheap flight from Panama City to Santo Domingo is a piece of cake with Price Alerts. All you need to do is create one of these automatic alerts and we'll get in touch as soon as the price has dropped.

  • Tailor your flights using filters. Pick your ideal departure and arrival times, airlines and total journey duration. You can also sort your results by 'Cheapest,' 'Best' or 'Fastest' Panama City to Santo Domingo flights.

Flying from Panama City

Tocumen International Airport (PTY)

  • Jet off from Tocumen International Airport (PTY) on a nonstop flight from Panama City to Santo Domingo. From PTY, you can fly directly into Las Americas International Airport (SDQ).

  • Copa Airlines is a popular carrier that offers direct Panama City to Santo Domingo plane tickets from PTY.

  • We make it a cinch to find a Panama City to Santo Domingo flight with a stopover. To see all the options departing from Tocumen International Airport, deselect 'Direct flights only.' Then, choose a flight offering a stop long enough to explore your chosen city. Popular stopovers include:

    • Luis Munoz Marin International Airport (SJU)

    • Reina Beatrix International Airport (AUA)

    • Miami International Airport (MIA)

  • Travelling from central Panama City to PTY takes around 1 hour 5 minutes on public transport. If you ride-share, drive or take a cab, you'll cover the 18 kilometres in 20 minutes or so, depending on traffic conditions.

  • After a stress-free start to your journey? Stay near Tocumen International Airport. Whether you're catching an early flight from Panama City to Santo Domingo or want to avoid feeling rushed, these hotels are just the thing:

  • 86.03% of flights departing from Tocumen International Airport reach their destination on time. Given its strong on-time performance, disruptions are unlikely when jetting out of PTY.

Panama Pacifico Airport (BLB)

  • Split up your Panama City to Santo Domingo flight with a stop so you can recharge or cross another place off your list. Some top stopovers between Panama Pacifico Airport and Santo Domingo are:

    • El Dorado International Airport (BOG)

    • Rafael Nunez International Airport (CTG)

    • Juan Santamaria International Airport (SJO)

  • BLB is around 11 kilometres from central Panama City. It'll take you 20 minutes or so to reach the airport driving from the city centre.

  • Want to treat yourself to an extra night away before catching your flight from Panama City to Santo Domingo? Unwind in a hotel near Panama Pacifico Airport before your adventure officially begins. Consider one of these stays:

  • Panama Pacifico Airport has a track record for punctuality. 86.75% of flights out of here make it to their final destination as planned.

Arriving in Santo Domingo

Las Americas International Airport (SDQ)

Dr. Joaquin Balaguer International Airport (JBQ)

  • Central Santo Domingo is about 13 kilometres from Dr. Joaquin Balaguer International Airport (JBQ). As soon as your flight from Panama City to Santo Domingo has hit the runway and you've made your way to arrivals, the drive should be around 25 minutes.

  • You'll find a few comfortable places to rest your head within a quick drive of JBQ. Get into relaxation mode at Moderno Apartamento Para tu Estancia after your Panama City to Santo Domingo flight.

  • Why be tied to someone else's timetable? Grab a Dr. Joaquin Balaguer International Airport rental car and decide exactly where your journey goes. Reserve your wheels here with FlexWays.

  • Save time at the rental desk by completing your booking beforehand. Reserve your ride from JBQ in advance so you can just get the keys and go.

Best time to go to Santo Domingo

  • May is the quietest month for flights from Panama City to Santo Domingo, while January is the busiest. Figure out the best time to visit Santo Domingo based on whether you prefer a laid-back vibe or a lively atmosphere.

  • The warmest month in Santo Domingo is September, with temperatures ranging between 23ºC (73ºF) and 33ºC (91ºF). Book your Panama City to Santo Domingo ticket then if that's your definition of good weather.

  • If you want to travel in cooler conditions, search for a cheap flight from Panama City to Santo Domingo in February when temperatures average between 19ºC (66ºF) and 29ºC (84ºF).

More about Santo Domingo

  • After booking your flight from Panama City to Santo Domingo, choose a hotel that puts you where you want to be. Make one of these options your base for exploring Santo Domingo:

  • Every great adventure has to include some sightseeing. Alcazar de Colon, National Pantheon (Pantheon Nacional) and National Palace are must-visits when exploring Santo Domingo.

Explore more of Dominican Republic

  • Santo Domingo Este is just one of the many cities in Dominican Republic waiting to be discovered once you've seen the sights of Santo Domingo. Around 13 kilometres to the east, popular attractions include Museo Las Tres Aves, billeteros Park and Abuela Mota Final Resting Place.

  • San Pedro de Macorís is another well-known destination in Dominican Republic and is around 64 kilometres east of Santo Domingo. No trip is complete without experiencing El Parquecito, Patrimonio arquitectónico de la ciudad de San Pedro de Macoris and Museo Cultural San Pedro.

Plan the rest of your trip from Panama City to Santo Domingo

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.