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Cheap Flights from Mexico City (MEXA) to Panama City (PTYA)

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Compare Mexico City to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

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Flight deals from Mexico City to Panama City

Looking for a cheap last-minute deal or the best return flight from Mexico City to Panama City? Find the lowest prices on one-way and return tickets right here.
Panama City.$443 per passenger.Departing Sat, 28 Jun, returning Sun, 6 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Sat, 28 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 6 Jul, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Tue, 1 Jul, returning Sun, 24 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Tue, 1 Jul, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 24 Aug, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Sat, 28 Jun, returning Mon, 4 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Sat, 28 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 4 Aug, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Fri, 1 Aug, returning Fri, 8 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Fri, 1 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 8 Aug, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Thu, 3 Jul, returning Mon, 7 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 3 Jul, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 7 Jul, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Thu, 8 May, returning Fri, 9 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 8 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 9 May, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$443 per passenger.Departing Fri, 13 Jun, returning Mon, 16 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Fri, 13 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 16 Jun, arriving in Mexico City Juarez International.Price includes taxes and charges.From $443, select.
Panama City.$444 per passenger.Departing Thu, 29 May, returning Fri, 13 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 29 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 13 Jun, arriving in Mexico City Juarez International.Price includes taxes and charges.From $444, select.

Find the cheapest month to fly from Mexico City to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Mexico City to Panama City flights are currently cheapest in May.
May
from $443
Jun
from $443
Jul
from $443
Aug
from $443
Sep
from $482
Oct
from $482
Nov
from $482
Dec
from $566
Jan
from $559
Feb
from $559
Mar
from $559
Apr
from $562

Direct flights from Mexico City to Panama City

Alternative Mexico City to Panama City routes

Looking for the cheapest, fastest or easiest route from Mexico City to Panama City? You could fly into the following airports instead.

Mexico City to Panama City: Flight information

The things to know before you go.
Cheapest flight found$443
Cheapest month to flyMay
Average flight time3 hrs, 45 mins
Most popular airlineCopa
Average flights per week57

Finding cheap flights from Mexico City to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Mexico City to Panama City is $443. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
3 hours and 45 minutes is the average flight time from Mexico City to Panama City.
Copa, Emirates and Aeromexico fly direct from Mexico City to Panama City.
As of May 2025, there are 57 flights per week flying from Mexico City to Panama City.
The cheapest month to fly from Mexico City to Panama City is usually May 2025.
If you're flying from Mexico City, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $443.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Mexico City to Panama City on Thursday, 8 May 2025.
Yes – the average flight time is 3 hours and 45 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In May, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
The cheapest airline that flies to Panama City is Avianca. And the cheapest airline that flies to Balboa Airport is Copa.

Flying from Mexico City to Panama City: what you need to know

  • There are two main airports you can start your trip from in Mexico City. Explore your options leaving from Benito Juarez International Airport (MEX) or Santa Lucia Air Force Base Airport (NLU) when planning your flight from Mexico City to Panama City.

  • Tocumen International Airport (PTY) and Panama Pacifico Airport (BLB) are Panama City's major entry points.

  • The average time for a direct Mexico City to Panama City flight is 3 hours 45 minutes.

  • Panama City's timezone is UTC-5, which makes Panama City one hour ahead of Mexico City.

  • The most popular route for flights from Mexico City to Panama City is Benito Juarez International Airport (MEX) to {"defaultCase":"Tocumen International Airport","accusativeCase":"Tocumen International Airport","nominativeCase":"Tocumen International Airport","dativeCase":"Tocumen International Airport"} (PTY). You'll find 48 services connecting these two airports each week.

  • Leave plenty of time to get on your Mexico City to Panama City flight. As a rule of thumb, arrive two hours before international departures and an hour ahead for domestic flights.

  • You'll likely experience bigger queues in popular months like July. Arriving up to four hours in advance for international flights and two hours for a domestic departure will give you plenty of time for security and boarding.

How to find the cheapest flights from Mexico City to Panama City

  • Book seven months before you want to fly. Pricing trends suggest that this is the ideal window for finding cheap Mexico City to Panama City flights.

  • The best month for finding cheap plane tickets from Mexico City to Panama City is October. Use the 'Whole month' tool to compare all available prices, then select the dates that offer the lowest fares.

  • Snapping up a cheap flight from Mexico City to Panama City couldn't be easier with Price Alerts. Simply set up one of these automatic alerts and we'll notify you as soon as there's a better deal.

  • Select your ideal departure and arrival times, airlines and number of stops by using the filters. Alternatively, sort your Mexico City to Panama City flight results by 'Fastest,' 'Cheapest' or 'Best.'

Flying from Mexico City

Benito Juarez International Airport (MEX)

  • If you're searching for a direct flight from Mexico City to Panama City, you can leave from Benito Juarez International Airport (MEX). Travel from MEX to Tocumen International Airport (PTY) without making any stops.

  • Secure your Mexico City to Panama City plane tickets with Copa Airlines. This carrier is a top pick for direct flights from MEX.

  • Think about adding a stopover to possibly find a cheaper Mexico City to Panama City flight. Simply uncheck 'Direct flights only' when searching for departures from Benito Juarez International Airport. Take a break from travelling at one of these popular airports:

    • Juan Santamaria International Airport (SJO)

    • Cancun International Airport (CUN)

    • Miguel Hidalgo y Costilla International Airport (GDL)

  • The journey from central Mexico City to MEX takes around 55 minutes by public transport. If you ride-share, drive or grab a cab, you'll cover the 6 kilometres in 25 minutes or so, depending on traffic.

  • After a leisurely start to your break? Stay near Benito Juarez International Airport. Whether you're taking an early flight from Mexico City to Panama City or want to avoid feeling rushed, these hotels have you covered:

  • 80.91% of flights departing from Benito Juarez International Airport touch down at their destination on time. Given its strong on-time stats, you're unlikely to face delays when taking off from MEX.

Santa Lucia Air Force Base Airport (NLU)

  • You can catch a nonstop flight from Mexico City to Panama City leaving from Santa Lucia Air Force Base Airport (NLU). Kick off your travels at NLU and come in for landing at Tocumen International Airport (PTY).

  • From NLU, you can book a direct Mexico City to Panama City plane ticket with Copa Airlines.

  • Visit family or friends or just take a moment to stretch your legs with a stopover. If you'd like to break up your Mexico City to Panama City flight, check out these options when leaving from Santa Lucia Air Force Base Airport:

    • Cancun International Airport (CUN)

    • Felipe Carrillo Puerto Airport (TQO)

    • Miguel Hidalgo y Costilla International Airport (GDL)

  • NLU is about 32 kilometres from central Mexico City. It'll take 55 minutes or so to get to the airport in a car from the city centre. Public transport takes roughly 1 hour 45 minutes.

  • Getting the crew to the airport on time before your flight from {"defaultCase":"Mexico City","accusativeCase":"Mexico City","nominativeCase":"Mexico City","dativeCase":"Mexico City"} to Panama City is far easier when you stay near Santa Lucia Air Force Base Airport. Think about booking a room at Verticca Hotel the night before you fly out.

  • When it comes to flights staying on schedule, Santa Lucia Air Force Base Airport has an on-time arrival rate of 67.58%.

Arriving in Panama City

Tocumen International Airport (PTY)

  • Tocumen International Airport (PTY) is approximately 18 kilometres from the centre of Panama City. If you're catching a cab or a ride-share, the drive will take around 20 minutes.

  • If you're taking public transport, expect a journey time of about 1 hour 5 minutes.

  • Consider staying in a hotel near PTY if you have a late flight from Mexico City to Panama City. Pick one of these options and skip the long transfer:

  • Go where the road takes you with a Tocumen International Airport rental car. Pick up your wheels from Avis, Dollar or MEX and see more of Panama City and beyond.

  • Booking your vehicle from Tocumen International Airport about three weeks in advance boosts your odds of scoring a great price.

Marcos A. Gelabert International Airport (PAC)

  • Central Panama City is located around 2 kilometres from Marcos A. Gelabert International Airport (PAC). As soon as your flight from Mexico City to Panama City has touched down and you've navigated your way to arrivals, expect a drive of around 5 minutes.

  • You can expect the journey to take approximately 25 minutes on public transport.

  • Hang the 'Do not disturb' sign on your door and relax at a hotel near BLB. Here are a few options where you can tuck yourself in after your flight from Mexico City to Panama City:

  • The quickest way to get to where you're going is with a Marcos A. Gelabert International Airport rental car. Collect your wheels from Thrifty, Avis or Alamo and hit the road in a heartbeat.

  • Snap up the best price by securing your ride from PAC three weeks in advance. You can also expect to have a wider range of vehicles.

Panama Pacifico Airport (BLB)

  • Panama Pacifico Airport (BLB) is about 11 kilometres from central Panama City. It'll take you about 20 minutes to reach the city centre by ride-share or cab after your flight from Mexico City to Panama City.

  • Start your journey without stressing over how to reach your destination with a Panama Pacifico Airport rental car. Find your perfect set of wheels with trusted suppliers here like Sixt, Dollar and Thrifty.

  • About one week ahead of your flight from Mexico City to Panama City is the ideal time to secure your vehicle from BLB. You're more likely to find a cheaper rate or catch some early booking discounts.

Best time to go to Panama City

  • June is the most popular month for flights from Mexico City to Panama City. To escape the crowds, visit Panama City in February.

  • Lock in a Mexico City to Panama City ticket departing in March if you're eager to explore the city during its warmest month. You can expect temperatures in Panama City to range from 21ºC (70ºF) to 32ºC (90ºF).

  • Search for cheap flights from Mexico City to Panama City in February if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

  • Start your Panama City trip off on the right foot by choosing the perfect place to stay. As soon as you've booked your flight from Mexico City to Panama City, check out our selection of accommodation options including:

  • There are so many things to explore in this city it can be hard to work out where to start. Panama Canal Museum, Casco Viejo and Cinta Costera are highlights which should feature on any good Panama City itinerary.

Explore more of Panama

  • You've visited Panama City, now it's time to explore other corners of Panama. Travel about 6 kilometres north to San Miguelito to tick off its leading sights. From Iglesia Cristo Luz del Mundo to IDMJI SAN MIGUELITO and Iglesia Bautista Independiente Emanuel, there's plenty to keep you busy.

  • Around 11 kilometres north-east of Panama City, Juan Díaz is another essential stop in Panama. Experience this destination's highlights firsthand at Malecon Costa Del Este, El Patio Human Friendly and Parque Los Robles Sur.

Plan the rest of your trip from Mexico City to Panama City

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.